Now showing items 1-15 of 15

    • Apolipoprotein C-III as a Potential Modulator of the Association Between HDL-Cholesterol and Incident Coronary Heart Disease 

      Jensen, Majken Karoline; Rimm, Eric B.; Furtado, Jeremy Daniel; Sacks, Frank Martin (Blackwell Publishing Ltd, 2012)
      Background: High-density lipoproteins (HDL) are structurally and metabolically heterogeneous and subclasses with differential effects on coronary heart disease (CHD) might exist. Apolipoprotein (apo) C-III, a small ...
    • Associations between Recreational and Commuter Cycling, Changes in Cycling, and Type 2 Diabetes Risk: A Cohort Study of Danish Men and Women 

      Rasmussen, Martin G.; Grøntved, Anders; Blond, Kim; Overvad, Kim; Tjønneland, Anne; Jensen, Majken K.; Østergaard, Lars (Public Library of Science, 2016)
      Background: Cycling is a recreational activity and mode of commuting with substantial potential to improve public health in many countries around the world. The aim of this study was to examine prospective associations ...
    • Fatty Acid Desaturase Gene Variants, Cardiovascular Risk Factors, and Myocardial Infarction in the Costa Rica Study 

      Aslibekyan, S.; Jensen, Majken Karoline; Campos, Hannia; Linkletter, C. D.; Loucks, E. B.; Ordovas, J. M.; Deka, R.; Rimm, Eric B.; Baylin, A. (Frontiers Research Foundation, 2012)
      Genetic variation in fatty acid desaturases (FADS) has previously been linked to long-chain polyunsaturated fatty acids (PUFAs) in adipose tissue and cardiovascular risk. The goal of our study was to test associations ...
    • Fluorescent Oxidation Products and Risk of Coronary Heart Disease: A Prospective Study in Women 

      Jensen, Majken K.; Wang, Yushan; Rimm, Eric B.; Townsend, Mary K.; Willett, Walter; Wu, Tianying (Blackwell Publishing Ltd, 2013)
      Background: Oxidative stress is implicated in the etiology of coronary heart disease (CHD). New measures to capture oxidative stress are warranted. Fluorescent oxidation products (FlOPs) can be measured in plasma and have ...
    • Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies 

      Qi, Qibin; Chu, Audrey Y; Kang, Jae H; Huang, Jinyan; Rose, Lynda M; Jensen, Majken K; Liang, Liming; Curhan, Gary C; Pasquale, Louis R; Wiggs, Janey L; De Vivo, Immaculata; Chan, Andrew T; Choi, Hyon K; Tamimi, Rulla M; Ridker, Paul M; Hunter, David J; Willett, Walter C; Rimm, Eric B; Chasman, Daniel I; Hu, Frank B; Qi, Lu (BMJ Publishing Group Ltd., 2014)
      Objective: To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity. Design: Prospective cohort study. Setting: Health professionals in the ...
    • Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry 

      Ahmad, Shafqat; Rukh, Gull; Varga, Tibor V.; Ali, Ashfaq; Kurbasic, Azra; Shungin, Dmitry; Ericson, Ulrika; Koivula, Robert W.; Chu, Audrey Y.; Rose, Lynda M.; Ganna, Andrea; Qi, Qibin; Stančáková, Alena; Sandholt, Camilla H.; Elks, Cathy E.; Curhan, Gary; Jensen, Majken K.; Tamimi, Rulla M.; Allin, Kristine H.; Jørgensen, Torben; Brage, Soren; Langenberg, Claudia; Aadahl, Mette; Grarup, Niels; Linneberg, Allan; Paré, Guillaume; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Boehnke, Michael; Hamsten, Anders; Mohlke, Karen L.; Pasquale, Louis T.; Pedersen, Oluf; Scott, Robert A.; Ridker, Paul M.; Ingelsson, Erik; Laakso, Markku; Hansen, Torben; Qi, Lu; Wareham, Nicholas J.; Chasman, Daniel I.; Hallmans, Göran; Hu, Frank B.; Renström, Frida; Orho-Melander, Marju; Franks, Paul W. (Public Library of Science, 2013)
      Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. ...
    • Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies 

      Qi, Qibin; Forman, John P.; Jensen, Majken K.; Flint, Alan; Curhan, Gary C.; Rimm, Eric B.; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure ...
    • Genetically Elevated Fetuin-A Levels, Fasting Glucose Levels, and Risk of Type 2 Diabetes: The Cardiovascular Health Study* 

      Jensen, Majken K.; Bartz, Traci M.; Djoussé, Luc; Kizer, Jorge R.; Zieman, Susan J.; Rimm, Eric B.; Siscovick, David S.; Psaty, Bruce M.; Ix, Joachim H.; Mukamal, Kenneth J. (American Diabetes Association, 2013)
      OBJECTIVE Fetuin-A levels are associated with higher risk of type 2 diabetes, but it is unknown if the association is causal. We investigated common (>5%) genetic variants in the fetuin-A gene (AHSG) fetuin-A levels, fasting ...
    • Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium 

      Dehghan, Abbas; Bis, Joshua C.; White, Charles C.; Smith, Albert Vernon; Morrison, Alanna C.; Cupples, L. Adrienne; Trompet, Stella; Chasman, Daniel I.; Lumley, Thomas; Völker, Uwe; Buckley, Brendan M.; Ding, Jingzhong; Jensen, Majken K.; Folsom, Aaron R.; Kritchevsky, Stephen B.; Girman, Cynthia J.; Ford, Ian; Dörr, Marcus; Salomaa, Veikko; Uitterlinden, André G.; Eiriksdottir, Gudny; Vasan, Ramachandran S.; Franceschini, Nora; Carty, Cara L.; Virtamo, Jarmo; Demissie, Serkalem; Amouyel, Philippe; Arveiler, Dominique; Heckbert, Susan R.; Ferrières, Jean; Ducimetière, Pierre; Smith, Nicholas L.; Wang, Ying A.; Siscovick, David S.; Rice, Kenneth M.; Wiklund, Per-Gunnar; Taylor, Kent D.; Evans, Alun; Kee, Frank; Rotter, Jerome I.; Karvanen, Juha; Kuulasmaa, Kari; Heiss, Gerardo; Kraft, Peter; Launer, Lenore J.; Hofman, Albert; Markus, Marcello R. P.; Rose, Lynda M.; Silander, Kaisa; Wagner, Peter; Benjamin, Emelia J.; Lohman, Kurt; Stott, David J.; Rivadeneira, Fernando; Harris, Tamara B.; Levy, Daniel; Liu, Yongmei; Rimm, Eric B.; Jukema, J. Wouter; Völzke, Henry; Ridker, Paul M.; Blankenberg, Stefan; Franco, Oscar H.; Gudnason, Vilmundur; Psaty, Bruce M.; Boerwinkle, Eric; O'Donnell, Christopher J. (Public Library of Science, 2016)
      Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a ...
    • Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study 

      Jung, Seungyoun; Smith-Warner, Stephanie A.; Willett, Walter C.; Wang, Molin; Wu, Tianying; Jensen, Majken; Hankinson, Susan E.; Eliassen, A. Heather (MDPI, 2016)
      Healthy diets may lower oxidative stress and risk of chronic diseases. However, no previous studies examined associations between diet and fluorescent oxidation products (FlOP), a global marker of oxidative stress. We ...
    • Interaction between Obesity and the NFKB1 - 94ins/delATTG Promoter Polymorphism in Relation to Incident Acute Coronary Syndrome: A Follow Up Study in Three Independent Cohorts 

      Stegger, Jakob Gerhard; Schmidt, Erik Berg; Berentzen, Tina Landsvig; Tjønneland, Anne; Vogel, Ulla; Rimm, Eric B.; Sørensen, Thorkild I. A.; Overvad, Kim; Jensen, Majken Karoline (Public Library of Science, 2013)
      Introduction: The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the ...
    • Multilocus Heterozygosity and Coronary Heart Disease: Nested Case-Control Studies in Men and Women 

      Mukamal, Kenneth J.; Jensen, Majken K.; Pers, Tune H.; Pai, Jennifer K.; Kraft, Peter; Rimm, Eric B. (Public Library of Science, 2015)
      Background: Generalized allelic heterozygosity has been proposed to improve reproductive fitness and has been associated with higher blood pressure, but its association with chronic disease is not well characterized. ...
    • Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD 

      Saccone, Nancy L.; Culverhouse, Robert C.; Schwantes-An, Tae-Hwi; Cannon, Dale S.; Chen, Xiangning; Cichon, Sven; Giegling, Ina; Han, Shizhong; Han, Younghun; Keskitalo-Vuokko, Kaisu; Kong, Xiangyang; Landi, Maria Teresa; Ma, Jennie Z.; Stephens, Sarah H.; Stevens, Victoria L.; Sun, Lingwei; Wang, Yufei; Wenzlaff, Angela S.; Aggen, Steven H.; Breslau, Naomi; Broderick, Peter; Chatterjee, Nilanjan; Chen, Jingchun; Heath, Andrew C.; Heliövaara, Markku; Hoft, Nicole R.; Montgomery, Grant W.; Niu, Tianhua; Payne, Thomas J.; Peltonen, Leena; Pergadia, Michele L.; Rice, John P.; Sherva, Richard; Spitz, Margaret R.; Sun, Juzhong; Witt, Stephanie H.; Yang, Bao-Zhu; Caporaso, Neil E.; Ehringer, Marissa A.; Eisen, Tim; Gapstur, Susan M.; Gelernter, Joel; Houlston, Richard; Kaprio, Jaakko; Kendler, Kenneth S.; Kraft, Peter; Leppert, Mark F.; Madden, Pamela A. F.; Nöthen, Markus M.; Pillai, Sreekumar; Rietschel, Marcella; Rujescu, Dan; Schwartz, Ann; Amos, Christopher I.; Bierut, Laura J.; Short, Susan; Hunter, David J.; Jensen, Majken Karoline; Martin, Nicholas G.; Li, Ming D.; Wang, Jen C.; Weiss, Robert B.; Wheeler, William (Public Library of Science, 2010)
      Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic ...
    • Urinary uromodulin, kidney function and cardiovascular disease in elderly adults 

      Garimella, Pranav S.; Biggs, Mary L.; Katz, Ronit; Ix, Joachim H.; Bennett, Michael R.; Devarajan, Prasad; Kestenbaum, Bryan R.; Siscovick, David S.; Jensen, Majken K.; Shlipak, Michael G.; Chaves, Paulo H. M.; Sarnak, Mark J. (2015)
      Urinary uromodulin (uUMOD) is the most common secreted tubular protein in healthy adults. However, the relationship between uUMOD and clinical outcomes is still unclear. Here we measured uUMOD in 192 participants of the ...
    • Use of Systems Biology Approaches to Analysis of Genome-Wide Association Studies of Myocardial Infarction and Blood Cholesterol in the Nurses' Health Study and Health Professionals’ Follow-Up Study 

      Reilly, Dermot; Hao, Ke; Jensen, Majken K.; Girman, Cynthia J.; Rimm, Eric B. (Public Library of Science, 2013)
      With the advance of genome-wide association studies and newly identified SNP (single-nucleotide polymorphism) associations with complex disease, important discoveries have emerged focusing not only on individual genes but ...