Now showing items 1-20 of 36

    • Acinar Cystadenoma of the Pancreas 

      Khor, Tze S.; Badizadegan, Kamran; Ferrone, Cristina Rosa; Fernandez-Del Castillo, Carlos F.; Desai, Gaurav S.; Saenz, Adam; Le, Long Phi; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      Pancreatic acinar cystadenomas (ACAs) are rare cystic lesions showing acinar differentiation with benign outcome. Although debated, ACAs are favored to be neoplastic and potentially the benign counterpart of acinar ...
    • Adenomatous and Foveolar Gastric Dysplasia: Distinct Patterns of Mucin Expression and Background Intestinal Metaplasia 

      Park, Do Youn; Srivastava, Amitabh; Kim, Gwang Ha; Mino-Kenudson, Mari; Deshpande, Vikram; Zukerberg, Lawrence R.; Song, Geum Am; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous (or intestinal) and foveolar (or gastric) types. Although limited genetic differences have been demonstrated between these subtypes, ...
    • Autoimmune pancreatitis-related cholecystitis: a morphologically and immunologically distinctive form of lymphoplasmacytic sclerosing cholecystitis 

      Wang, Wei-Lia; Farris, Alton B; Lauwers, Gregory Y.; Deshpande, Vikram (Wiley-Blackwell, 2009)
      Aims: Gallbladder involvement in autoimmune pancreatitis (AIP) is reported to be histologically similar to that seen in primary sclerosing cholangitis (PSC) and biliary obstruction secondary to pancreatic ductal adenocarcinoma ...
    • Autoimmune pancreatitis-related diabetes: quantitative analysis of endocrine islet cells and inflammatory infiltrate 

      Farris, Alton B.; Lauwers, Gregory Y.; Deshpande, Vikram (Springer Nature, 2010)
      In autoimmune pancreatitis (AIP), mechanism(s) of paradoxical glycemic control improvement (GCI) often occurring after pancreatic resection and steroid therapy are not fully elucidated. Using image quantitation, AIP cases ...
    • CDX2 Expression in the Intestinal-Type Gastric Epithelial Neoplasia: Frequency and Significance. 

      Park, Do Youn; Srivastava, Amitabh; Kim, Gwang Ha; Mino-Kenudson, Mari; Deshpande, Vikram; Zukerberg, Lawrence R.; Song, Geum Am; Lauwers, Gregory Y. (Nature Publishing Group, 2010)
      CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells. In gastric adenocarcinoma, CDX2 expression is known to be associated with limited ...
    • Chronic Sclerosing Sialadenitis (Küttner Tumor) Is an IgG4-associated Disease 

      Geyer, Julia Turbiner; Ferry, Judith Ann; Harris, Nancy Lee; Stone, John H; Zukerberg, Lawrence R.; Lauwers, Gregory Y.; Pilch, Ben Z.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2010)
      BACKGROUND: Chronic sclerosing sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior Asian study proposed that chronic sclerosing sialadenitis is a ...
    • The Clinical Significance of Incidental Chronic Colitis: A Study of 17 Cases 

      Deshpande, Vikram; Hsu, MayLee; Kumarasinghe, M. Priyanthi; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Introduction: A histologic diagnosis of chronic colitis raises a relatively limited differential diagnosis that includes inflammatory bowel disease, long-standing infections, and chronic ischemia. In routine clinical ...
    • Consensus Statement on the Pathology of IgG4-Related Disease 

      Deshpande, Vikram; Zen, Yoh; Chan, John KC; Yi, Eunhee E; Sato, Yasuharu; Yoshino, Tadashi; Klöppel, Günter; Heathcote, J Godfrey; Khosroshahi, Arezou; Ferry, Judith Ann; Aalberse, Rob C; Bloch, Donald Bendit; Brugge, William Robert; Bateman, Adrian C; Carruthers, Mollie Nicole; Chari, Suresh T; Cheuk, Wah; Cornell, Lynn D; Fernandez-Del Castillo, Carlos F.; Forcione, David G.; Hamilos, Daniel L.; Kamisawa, Terumi; Kasashima, Satomi; Kawa, Shigeyuki; Kawano, Mitsuhiro; Lauwers, Gregory Y.; Masaki, Yasufumi; Nakanuma, Yasuni; Notohara, Kenji; Okazaki, Kazuichi; Ryu, Ji Kon; Saeki, Takako; Sahani, Dushyant V.; Smyrk, Thomas C; Stone, James Robert; Takahira, Masayuki; Webster, George J; Yamamoto, Motohisa; Zamboni, Giuseppe; Umehara, Hisanori; Stone, John H (Nature Publishing Group, 2012)
      IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: a tendency to form tumefactive lesions in multiple sites; a characteristic histopathological appearance; and—often ...
    • Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma 

      Kelly, Paul J.; Shinagare, Shweta; Sainani, Nisha I.; Hong, Xiao; Ferrone, Cristina Rosa; Yilmaz, Omer Hidir; Fernandez-Del Castillo, Carlos F.; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      INTRODUCTION: The prototypic pancreatic ductal adenocarcinoma shows small-caliber glands that are placed within an exuberant desmoplastic stromal reaction. A number of histologic patterns have been described, and the ...
    • Development of an IgG4-RD Responder Index 

      Carruthers, Mollie Nicole; Stone, John H.; Deshpande, Vikram; Khosroshahi, Arezou (Hindawi Publishing Corporation, 2012)
      IgG4-related disease (IgG4-RD) is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are ...
    • Does Autoimmune Pancreatitis Increase the Risk of Pancreatic Carcinoma? 

      Gupta, Rajib; Khosroshahi, Arezou; Shinagare, Shweta; Fernandez, Carlos; Ferrone, Cristina Rosa; Lauwers, Gregory Y.; Stone, John H; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2013)
      OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and ...
    • Does the Mechanism of Lymph Node Invasion Affect Survival in Patients with Pancreatic Ductal Adenocarcinoma? 

      Konstantinidis, Ioannis T; Deshpande, Vikram; Hui, Hui; Wargo, Jennifer Ann; Fernandez-Del Castillo, Carlos F.; Thayer, Sarah P.; Androutsopoulos, Vasiliki; Lauwers, Gregory Y.; Warshaw, Andrew Louis; Ferrone, Cristina Rosa (Springer Science + Business Media, 2010)
      Background: Lymph node metastases are prognostically significant in pancreatic ductal adenocarcinoma. Little is known about the significance of direct lymph node invasion. Aim: The aim of this study is to find out whether ...
    • Endoscopic Surveillance of Patients With Hereditary Diffuse Gastric Cancer: Biopsy Recommendations After Topographic Distribution of Cancer Foci in a Series of 10 CDH1-mutated Gastrectomies 

      Fujita, Hiroshi; Lennerz, Jochen K.M.; Chung, Daniel Chulyong; Patel, Devanshi; Deshpande, Vikram; Yoon, Sam; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2012)
      The management of hereditary diffuse-type gastric cancer revolves around surveillance biopsies and the timing of prophylactic gastrectomy. In the absence of a validated surveillance biopsy protocol, we modeled bioptic ...
    • Gastric Hyperplastic Polyps: A Heterogeneous Clinicopathologic Group Including a Distinct Subset Best Categorized as Mucosal Prolapse Polyp 

      Gonzalez-Obeso, Elvira; Fujita, Hiroshi; Deshpande, Vikram; Ogawa, Fumihiro; Lisovsky, Mikhail; Genevay, Muriel; Grzyb, Krzysztof; Brugge, William Robert; Lennerz, Jochen K.; Shimizu, Michio; Srivastava, Amitabh; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2011)
      BACKGROUND: Gastric hyperplastic polyps are the second most common subtype of gastric polyps. There has been an ongoing debate about their precise diagnostic criteria and etiological associations. MATERIALS AND METHODS: A ...
    • Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues 

      Zhu, Jiang; Adli, Mazhar; Zou, James Y.; Verstappen, Griet; Coyne, Michael J.; Zhang, Xiaolan; Durham, Timothy; Miri, Mohammad; Deshpande, Vikram; De Jager, Philip L.; Bennett, David A.; Houmard, Joseph A.; Muoio, Deborah M.; Onder, Tamer T.; Camahort, Raymond; Cowan, Chad A.; Meissner, Alexander; Epstein, Charles B.; Shoresh, Noam; Bernstein, Bradley E. (Elsevier BV, 2013)
      Differences in chromatin organization are key to the multiplicity of cell states that arise from a single genetic background, yet the landscapes of in vivo tissues remain largely uncharted. Here, we mapped chromatin ...
    • Global Genomic Analysis of Intraductal Papillary Mucinous Neoplasms of the Pancreas Reveals Significant Molecular Differences Compared to Ductal Adenocarcinoma 

      Fritz, Stefan; Fernandez-Del Castillo, Carlos F.; Mino-Kenudson, Mari; Crippa, Stefano; Deshpande, Vikram; Lauwers, Gregory Y.; Warshaw, Andrew Louis; Thayer, Sarah P.; Iafrate, Anthony John (Ovid Technologies (Wolters Kluwer Health), 2009)
      Objective: To determine whether intraductal papillary mucinous neoplasms of the pancreas (IPMNs) have a different genetic background compared with ductal adenocarcinoma (PDAC). Summary Background Data: The biologic and ...
    • Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability 

      Luther, Jay; Garber, John J.; Khalili, Hamed; Dave, Maneesh; Bale, Shyam Sundhar; Jindal, Rohit; Motola, Daniel L.; Luther, Sanjana; Bohr, Stefan; Jeoung, Soung Won; Deshpande, Vikram; Singh, Gurminder; Turner, Jerrold R.; Yarmush, Martin L.; Chung, Raymond T.; Patel, Suraj J. (2015)
      BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ...
    • High fat diet enhances stemness and tumorigenicity of intestinal progenitors 

      Beyaz, Semir; Mana, Miyeko D.; Roper, Jatin; Kedrin, Dmitriy; Saadatpour, Assieh; Hong, Sue-Jean; Bauer-Rowe, Khristian E.; Xifaras, Michael E.; Akkad, Adam; Arias, Erika; Pinello, Luca; Katz, Yarden; Shinagare, Shweta; Abu-Remaileh, Monther; Mihaylova, Maria M.; Lamming, Dudley W.; Dogum, Rizkullah; Guo, Guoji; Bell, George W.; Selig, Martin; Nielsen, G. Petur; Gupta, Nitin; Ferrone, Cristina R.; Deshpande, Vikram; Yuan, Guo-Cheng; Orkin, Stuart H.; Sabatini, David M.; Yilmaz, Ömer H. (2016)
      Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem-cells (ISCs) ...
    • IgG4+ to IgG+ Plasma Cells Ratio of Ampulla Can Help Differentiate Autoimmune Pancreatitis From Other “Mass Forming” Pancreatic Lesions 

      Sepehr, Alireza; Mino-Kenudson, Mari; Ogawa, Fumihiro; Brugge, William Robert; Deshpande, Vikram; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Autoimmune pancreatitis (AIP) shows a unique spectrum of histologic features and commonly presents with an abundant IgG4-positive (IgG4+) plasma cell infiltration. However, differentiating AIP from other mass lesions, ...
    • IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material 

      Deshpande, Vikram; Sainani, Nisha I.; Chung, Raymond Taeyong; Pratt, Daniel S.; Mentha, Gilles; Rubbia-Brandt, Laura; Lauwers, Gregory Y. (Springer Nature, 2009)
      IgG4-associated cholangitis is a steroid-responsive hepatobiliary inflammatory condition associated with autoimmune pancreatitis that clinically and radiologically mimics primary sclerosing cholangitis. In this study, we ...