Browsing by Author "Dunn, Ian"

Now showing items 1-9 of 9

    • Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors 

      Eberlin, L. S.; Norton, I.; Orringer, D.; Dunn, Ian Frederick; Liu, X.; Ide, J. L.; Jarmusch, A. K.; Ligon, Keith Lloyd; Jolesz, Ferenc A.; Golby, Alexandra Jacqueline; Santagata, Sandro; Agar, Nathalie Marie Yvonne Rachel; Cooks, R. G. (Proceedings of the National Academy of Sciences, 2013)
      The main goal of brain tumor surgery is to maximize tumor resection while preserving brain function. However, existing imaging and surgical techniques do not offer the molecular information needed to delineate tumor ...

    • Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5 

      Abedalthagafi, Malak S.; Merrill, Parker H.; Bi, Wenya Linda; Jones, Robert T.; Listewnik, Marc L.; Ramkissoon, Shakti H.; Thorner, Aaron R.; Dunn, Ian F.; Beroukhim, Rameen; Alexander, Brian M.; Brastianos, Priscilla K.; Francis, Joshua M.; Folkerth, Rebecca D.; Ligon, Keith L.; Hummelen, Paul Van; Ligon, Azra H.; Santagata, Sandro (Impact Journals LLC, 2014)
      Meningiomas are a diverse group of tumors with a broad spectrum of histologic features. There are over 12 variants of meningioma, whose genetic features are just beginning to be described. Angiomatous meningioma is a World ...

    • CDK8 Is a Colorectal Cancer Oncogene That Regulates β-Catenin Activity 

      Firestein, Ron; Bass, Adam; Kim, So Young; Dunn, Ian Frederick; Silver, Serena J.; Guney, Isil; Freed, Ellen; Ligon, Azra Hadi; Vena, Natalie; Ogino, Shuji; Chheda, Milan; Tamayo, Pablo; Finn, Stephen; Shrestha, Yashaswi; Boehm, Jesse S.; Jain, Supriya Rani; Bojarski, Emeric; Mermel, Craig; Barretina, Jordi; Chan, Jennifer Ang; Baselga, Jose; Tabernero, Josep; Root, David E.; Fuchs, Charles Stewart; Loda, Massimo; Shivdasani, Ramesh Arjun; Meyerson, Matthew Langer; Hahn, William Chun (Springer Nature, 2008)
      Aberrant activation of the canonical Wnt/β-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated β-catenin activity drives colon tumorigenesis, ...

    • CK1\(\varepsilon\) is Required for Breast Cancers Dependent on \(\beta\)-Catenin Activity 

      Firestein, Ron; Gupta, Piyush; Repich, Kara; Silver, Serena J.; Boehm, Jesse S.; Kim, So Young; Dunn, Ian Frederick; Wardwell, Leslie; Schinzel, Anna; Wittner, Ben; Root, David E.; Ramaswamy, Sridhar; Lander, Eric Steven; Hahn, William C. (Public Library of Science, 2010)
      Background: Aberrant \(\beta\)-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate \(\beta\)-catenin activity for therapeutic purposes have ...

    • Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations 

      Brastianos, Priscilla K.; Horowitz, Peleg M.; Santagata, Sandro; Jones, Robert T.; McKenna, Aaron; Getz, Gad; Ligon, Keith L.; Palescandolo, Emanuele; Van Hummelen, Paul; Ducar, Matthew D.; Raza, Alina; Sunkavalli, Ashwini; MacConaill, Laura E.; Stemmer-Rachamimov, Anat O.; Louis, David N.; Hahn, William C.; Dunn, Ian F.; Beroukhim, Rameen (2013)
      Meningiomas are the most common primary nervous system tumor. The tumor suppressor NF2 is disrupted in approximately half of meningiomas1 but the complete spectrum of genetic changes remains undefined. We performed ...

    • Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma 

      Du, Ziming; Abedalthagafi, Malak; Aizer, Ayal A.; McHenry, Allison R.; Sun, Heather H.; Bray, Mark-Anthony; Viramontes, Omar; Machaidze, Revaz; Brastianos, Priscilla K.; Reardon, David A.; Dunn, Ian F.; Freeman, Gordon J.; Ligon, Keith L.; Carpenter, Anne E.; Alexander, Brian M.; Agar, Nathalie Y.; Rodig, Scott J.; Bradshaw, Elizabeth M.; Santagata, Sandro (Impact Journals LLC, 2015)
      There are no effective medical treatments for WHO grade III (anaplastic) meningioma. Patients with this high-grade malignancy have a median survival of less than two years. Therapeutics that modulate the mechanisms that ...

    • MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma 

      Miller, Michael B.; Bi, Wenya Linda; Ramkissoon, Lori A.; Kang, Yun Jee; Abedalthagafi, Malak; Knoff, David S.; Agarwalla, Pankaj K.; Wen, Patrick Y.; Reardon, David A.; Alexander, Brian M.; Laws, Edward R.; Dunn, Ian F.; Beroukhim, Rameen; Ligon, Keith L.; Ramkissoon, Shakti H. (Impact Journals LLC, 2016)
      Pituitary spindle cell oncocytoma (SCO) is an uncommon primary pituitary neoplasm that presents with mass effect on adjacent neurovascular structures, similar to non-hormone-producing pituitary adenomas. To determine the ...

    • Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications 

      Bi, Wenya Linda; Zhang, Michael; Wu, Winona W.; Mei, Yu; Dunn, Ian F. (Frontiers Media S.A., 2016)
      There has been a recent revolution in our understanding of the genetic factors that drive meningioma, punctuating an equilibrium that has existed since Cushing’s germinal studies nearly a century ago. A growing appreciation ...

    • The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery 

      Zada, Gabriel; Agarwalla, Pankaj Kumar; Mukundan, Srinivasan; Dunn, Ian Frederick; Golby, Alexandra J.; Laws, Edward R. (Journal of Neurosurgery Publishing Group (JNSPG), 2011)
      Object A considerable degree of variability exists in the anatomy of the sphenoid sinus, sella turcica, and surrounding skull base structures. The authors aimed to characterize neuroimaging and intraoperative variations ...