Browsing by Author "Losina, Elena"
Now showing items 1-20 of 59
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The “ART” of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa
Losina, Elena; Bassett, Ingrid; Giddy, Janet; Chetty, Senica; Regan, Susan; Walensky, Rochelle; Ross, Douglas; Scott, Callie A.; Uhler, Lauren M.; Katz, Jeffrey; Holst, Helga; Freedberg, Kenneth (Public Library of Science (PLoS), 2010-03-04)Background Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective ... -
Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS
Rydzak, Chara Elaine; Cotich, Kara L.; Sax, Paul Edward; Hsu, Heather Emery Smith; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth Alan; Weinstein, Milton C.; Goldie, Sue J. (2010)Background: Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ... -
Association between socioeconomic status and pain, function and pain catastrophizing at presentation for total knee arthroplasty
Feldman, Candace H; Dong, Yan; Katz, Jeffrey N; Donnell-Fink, Laurel A; Losina, Elena (BioMed Central, 2015)Background: Patients with higher socioeconomic status (SES) are shown to have better total knee arthroplasty (TKA) outcomes compared to those with lower SES. The relationship between SES and factors that influence TKA use ... -
Association of MRI findings and expert diagnosis of symptomatic meniscal tear among middle-aged and older adults with knee pain
Deshpande, Bhushan R.; Losina, Elena; Smith, Savannah R.; Martin, Scott D.; Wright, R. John; Katz, Jeffrey N. (BioMed Central, 2016)Background: Our aim was to examine the association between an expert clinician’s impression of symptomatic meniscal tears and subsequent MRI in the context of middle-aged and older adults with knee pain. Methods: Patients ... -
The AViKA (Adding Value in Knee Arthroplasty) postoperative care navigation trial: rationale and design features
Losina, Elena; Collins, Jamie E; Daigle, Meghan E; Donnell-Fink, Laurel A; Prokopetz, Julian JZ; Strnad, Doris; Lerner, Vladislav; Rome, Benjamin N; Ghazinouri, Roya; Skoniecki, Debra J; Katz, Jeffrey N; Wright, John (BioMed Central, 2013)Background: Utilization of total knee arthroplasty is increasing rapidly. A substantial number of total knee arthroplasty recipients have persistent pain after surgery. Our objective was to design a randomized controlled ... -
The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis
Hyle, Emily P.; Jani, Ilesh V.; Lehe, Jonathan; Su, Amanda E.; Wood, Robin; Quevedo, Jorge; Losina, Elena; Bassett, Ingrid V.; Pei, Pamela P.; Paltiel, A. David; Resch, Stephen; Freedberg, Kenneth A.; Peter, Trevor; Walensky, Rochelle P. (Public Library of Science, 2014)Background: Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to ... -
Clinical Impact and Cost-Effectiveness of Expanded Voluntary HIV Testing in India
Venkatesh, Kartik K.; Becker, Jessica E.; Kumarasamy, Nagalingeswaran; Nakamura, Yoriko M.; Mayer, Kenneth H.; Losina, Elena; Swaminathan, Soumya; Flanigan, Timothy P.; Walensky, Rochelle P.; Freedberg, Kenneth A. (Public Library of Science, 2013)Background: Despite expanding access to antiretroviral therapy (ART), most of the estimated 2.3 to 2.5 million HIV-infected individuals in India remain undiagnosed. The questions of whom to test for HIV and at what frequency ... -
Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age
Ciaranello, Andrea L.; Doherty, Kathleen; Penazzato, Martina; Lindsey, Jane C.; Harrison, Linda; Kelly, Kathleen; Walensky, Rochelle P.; Essajee, Shaffiq; Losina, Elena; Muhe, Lulu; Wools-Kaloustian, Kara; Ayaya, Samuel; Weinstein, Milton C.; Palumbo, Paul; Freedberg, Kenneth A. (Lippincott Williams & Wilkins, 2015)Background: The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with ... -
Cost-Effectiveness of HIV Testing Referral Strategies among Tuberculosis Patients in India
Uhler, Lauren M.; Kumarasamy, Nagalingeswaran; Saxena, Anjali; Muniyandi, Malaisamy; Stoler, Adam W.; Lu, Zhigang; Flanigan, Timothy P.; Bender, Melissa A.; Swaminathan, Soumya; Mayer, Kenneth H.; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth Alan; Swaminathan, Soumya (Public Library of Science, 2010)Background: Indian guidelines recommend routine referral for HIV testing of all tuberculosis (TB) patients in the nine states with the highest HIV prevalence, and selective referral for testing elsewhere. We assessed the ... -
Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire Appraisal
Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David; Balestre, Eric; Messou, Eugène; Dabis, François; Losina, Elena; Walensky, Rochelle P.; Weinstein, Milton C.; Freedberg, Kenneth Alan (Public Library of Science, 2009)Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was ... -
The Cost-Effectiveness of Tuberculosis Preventive Therapy for HIV-Infected Individuals in Southern India: A Trial-Based Analysis
Pho, Mai T.; Swaminathan, Soumya; Kumarasamy, Nagalingeswaran; Losina, Elena; Ponnuraja, C.; Uhler, Lauren M.; Scott, Callie A.; Mayer, Kenneth Hugh; Freedberg, Kenneth Alan; Walensky, Rochelle P. (Public Library of Science, 2012)Background: Regimens for isoniazid-based preventive therapy (IPT) for tuberculosis (TB) in HIV-infected individuals have not been widely adopted given concerns regarding efficacy, adherence and drug resistance. Further, ... -
Counselor- Versus Provider-Based HIV Screening in the Emergency Department: Results From the Universal Screening for HIV Infection in the Emergency Room (USHER) Randomized Controlled Trial
Walensky, Rochelle; Reichmann, William M.; Arbelaez, Christian; Wright, Elizabeth; Katz, Jeffrey; Seage, George; Safren, Steven A.; Hare, Anna Q.; Novais, Anna; Losina, Elena (Elsevier BV, 2011-07)Objective We compare rates of rapid HIV testing, test offer, and acceptance in an urban emergency department (ED) when conducted by dedicated HIV counselors versus current members of the ED staff. Methods The Universal ... -
Defining the Value of Future Research to Identify the Preferred Treatment of Meniscal Tear in the Presence of Knee Osteoarthritis
Losina, Elena; Dervan, Elizabeth E.; Paltiel, A. David; Dong, Yan; Wright, R. John; Spindler, Kurt P.; Mandl, Lisa A.; Jones, Morgan H.; Marx, Robert G.; Safran-Norton, Clare E.; Katz, Jeffrey N. (Public Library of Science, 2015)Background: Arthroscopic partial meniscectomy (APM) is extensively used to relieve pain in patients with symptomatic meniscal tear (MT) and knee osteoarthritis (OA). Recent studies have failed to show the superiority of ... -
Development and feasibility of a personalized, interactive risk calculator for knee osteoarthritis
Losina, Elena; Klara, Kristina; Michl, Griffin L.; Collins, Jamie E.; Katz, Jeffrey N. (BioMed Central, 2015)Background: The incidence of knee osteoarthritis (OA) is rising. While several risk factors have been associated with the development of knee OA, this information is not readily accessible to those at risk for osteoarthritis. ... -
Development and validation of an index of musculoskeletal functional limitations
Katz, Jeffrey Neil; Wright, Elizabeth A; Baron, John A; Losina, Elena (Springer Nature, 2009)Background: While musculoskeletal problems are leading sources of disability, there has been little research on measuring the number of functionally limiting musculoskeletal problems for use as predictor of outcome in ... -
Diagnostic Accuracy of a Point-of-Care Urine Test for Tuberculosis Screening Among Newly-Diagnosed HIV-Infected Adults: A Prospective, Clinic-Based Study
Drain, Paul K.; Losina, Elena; Coleman, Sharon M.; Giddy, Janet; Ross, Douglas; Katz, Jeffrey; Walensky, Rochelle; Freedberg, Kenneth; Bassett, Ingrid (Springer Science and Business Media LLC, 2014-02-26)Background A rapid diagnostic test for active tuberculosis (TB) at the clinical point-of-care could expedite case detection and accelerate TB treatment initiation. We assessed the diagnostic accuracy of a rapid urine ... -
Diagnostic accuracy of administrative data algorithms in the diagnosis of osteoarthritis: a systematic review
Shrestha, Swastina; Dave, Amish Jayant; Losina, Elena; Katz, Jeffrey Neil (Springer Science and Business Media LLC, 2016-07-07)Background: Administrative health care data are frequently used to study disease burden and treatment outcomes in many conditions including osteoarthritis (OA). OA is a chronic condition with significant disease burden ... -
Differences in Self-Reported Health in the Osteoarthritis Initiative (OAI) and Third National Health and Nutrition Examination Survey (NHANES-III)
Reichmann, William M.; Katz, Jeffrey Neil; Losina, Elena; Reichmann, William (Public Library of Science (PLoS), 2011-02-28)Objective: To assess self-reported health status (SRHS) in two cohorts of participants with radiographic knee osteoarthritis (OA) and examine the extent that differences in SRHS are due to study design. Method: We used ... -
Does Modality of Survey Administration Impact Data Quality: Audio Computer Assisted Self Interview (ACASI) Versus Self-Administered Pen and Paper?
Reichmann, William M.; Losina, Elena; Seage, George; Arbelaez, Christian; Safren, Steven A.; Katz, Jeffrey; Hetland, Adam; Walensky, Rochelle (Public Library of Science (PLoS), 2010-01-15)Background In the context of a randomized controlled trial (RCT) on HIV testing in the emergency department (ED) setting, we evaluated preferences for survey modality and data quality arising from each modality. Meth ... -
Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa
Hom, Jeffrey K.; Wang, Bingxia; Chetty, Senica; Giddy, Janet; Mazibuko, Matilda; Allen, Jenny; Walensky, Rochelle P.; Losina, Elena; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2012)Objective: To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa. Design ...