Browsing by Author "Neumann, Constanze N."

Now showing items 1-5 of 5

    • Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation 

      Kamlet, Adam; Neumann, Constanze Nicole; Lee, Eunsung; Carlin, Stephen M.; Moseley, Christian K.; Stephenson, Nickeisha A; Hooker, Jacob M; Ritter, Tobias (Public Library of Science, 2013)
      New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of ...

    • Concerted nucleophilic aromatic substitution with 19F− and 18F− 

      Neumann, Constanze N.; Hooker, Jacob M.; Ritter, Tobias (2016)
      Nucleophilic aromatic substitution (SNAr) is widely used by organic chemists to functionalize aromatic molecules, and it is the most commonly used method to generate arenes that contain a 18F for use in PET imaging.1 A ...

    • A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging 

      Lee, Eunsung; Kamlet, Adam Seth; Powers, David C.; Neumann, Constanze Nicole; Boursalian, Gregory Bagrad; Furuya, Takeru; Choi, Daniel C.; Hooker, Jacob M.; Ritter, Tobias (American Association for the Advancement of Science, 2011)
      The unnatural isotope fluorine-18 \((^{18}F)\) is used as a positron emitter in molecular imaging. Currently, many potentially useful \(^{18}F\)-labeled probe molecules are inaccessible for imaging because no fluorination ...

    • Introduction of Fluorine and Fluorine-Containing Functional Groups 

      Liang, Theresa; Neumann, Constanze Nicole; Ritter, Tobias (Wiley-VCH Verlag Berlin, 2013)
      Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis. The most challenging transformation remains the formation ...

    • Late-Stage Fluorination With 19F− and 18F− via Concerted Nucleophilic Aromatic Substitution 

      Neumann, Constanze N. (2016-09-09)
      The formation of C–F bonds has long been considered a challenging transformation and C–F bonds commonly had to be formed early on in a synthetic sequence towards complex organofluorides. Late-stage fluorination reactions ...