Now showing items 1-6 of 6

    • Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma 

      Roh, Miin; Zhang, Yan; Murakami, Yusuke; Thanos, Aristomenis; Lee, Sung Chul; Vavvas, Demetrios; Benowitz, Larry Ira; Miller, Joan Whitten (Public Library of Science, 2012)
      Background: Visual loss in glaucoma is associated with pathological changes in retinal ganglion cell (RGC) axons and a slow decline in the RGC population. Age and elevated intraocular pressure (IOP) are the main risk factors ...
    • The impact of discrete modes of spinal cord injury on bladder muscle contractility 

      Seth, Abhishek; Chung, Yeun Goo; Kim, Daniel; Ramachandran, Aruna; Cristofaro, Vivian; Gomez III, Pablo; Tu, Duong D; Huang, Lin; Benowitz, Larry Ira; Di Vizio, Dolores; Sullivan, Maryrose P.; Adam, Rosalyn Mare (BioMed Central, 2013)
      Background: Prior studies have compared the effect of spinal cord injury elicited using distinct approaches on motor and visceral function. However, the impact of such discrete modes of injury specifically on bladder muscle ...
    • Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury 

      Kim, Daniel; Zai, Laila; Liang, Peng; Schaffling, Colleen; Ahlborn, David; Benowitz, Larry I. (Public Library of Science, 2013)
      Although corticospinal tract axons cannot regenerate long distances after spinal cord injury, they are able to sprout collateral branches rostral to an injury site that can help form compensatory circuits in cases of ...
    • Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury 

      Chung, Yeun Goo; Seth, Abhishek; Doyle, Claire; Franck, Debra; Kim, Daniel; Cristofaro, Vivian; Benowitz, Larry I.; Tu, Duong D.; Estrada, Carlos R.; Mauney, Joshua R.; Sullivan, Maryrose P.; Adam, Rosalyn M. (Public Library of Science, 2015)
      Neurogenic detrusor overactivity and the associated loss of bladder control are among the most challenging complications of spinal cord injury (SCI). Anticholinergic agents are the mainstay for medical treatment of detrusor ...
    • NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans 

      Dickendesher, Travis L.; Baldwin, Katherine T.; Mironova, Yevgeniya A.; Koriyama, Yoshiki; Raiker, Stephen J; Askew, Kim L.; Wood, Andrew; Geoffroy, Cédric G.; Zheng, Binhai; Liepmann, Claire D.; Katagiri, Yasuhiro; Benowitz, Larry Ira; Geller, Herbert M.; Giger, Roman J. (Nature, 2012)
      In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin–associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family ...
    • Regeneration in the aging peripheral nervous system 

      Painter, Michio Wendell (2014-06-06)
      In the peripheral nervous system (PNS), aging is associated with a number of disorders, including a decline in regenerative capacity after injury. Although this decline has been observed in both rodents and humans for ...