Now showing items 1-15 of 15

    • CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival 

      D’Addio, Francesca; Ueno, Takuya; Clarkson, Michael; Zhu, Baogong; Vergani, Andrea; Freeman, Gordon James; Sayegh, Mohamed Hassan; Ansari, Mohammed Javeed I.; Fiorina, Paolo; Habicht, Antje (Public Library of Science, 2013)
      CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8+ cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, ...
    • Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection 

      Vergani, Andrea; Fotino, Carmen; D’Addio, Francesca; Tezza, Sara; Podetta, Michele; Gatti, Francesca; Chin, Melissa; Bassi, Roberto; Molano, Ruth D.; Corradi, Domenico; Gatti, Rita; Ferrero, Maria E.; Secchi, Antonio; Grassi, Fabio; Ricordi, Camillo; Sayegh, Mohamed H.; Maffi, Paola; Pileggi, Antonello; Fiorina, Paolo (American Diabetes Association, 2013)
      The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2XRs) sense ATP released during cell damage-activation, thus regulating T-cell activation. We aim to define the role of P2XRs during islet allograft ...
    • IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response 

      Petrelli, Alessandra; Carvello, Michele; Du, Ming; Chengwen, Liu; Mfarrej, Bechara G.; Hwu, Patrick; Secchi, Antonio; Leonard, Warren J.; Young, Deborah; Zajac, Allan J.; Vergani, Andrea; Lee, Kang Mi; Tezza, Sara; Kleffel, Sonja Beate; Sayegh, Mohamed Hassan; Markmann, James F.; Fiorina, Paolo (American Diabetes Association, 2011)
      Objective: Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still ...
    • Immunomodulation by Mesenchymal Stem Cells A Potential Therapeutic Strategy for Type 1 Diabetes 

      Abdi, Reza; Fiorina, Paolo; Adra, Chaker N.; Atkinson, Mark; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have the potential to give rise to cells of diverse lineages. Interestingly, MSCs can be found in virtually all postnatal tissues. The main criteria currently ...
    • Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses 

      Carvello, Michele; Petrelli, Alessandra; Vergani, Andrea; Lee, Kang Mi; Tezza, Sara; Chin, Melissa; Orsenigo, Elena; Staudacher, Carlo; Secchi, Antonio; Dunussi-Joannopoulos, Kyri; Sayegh, Mohamed Hassan; Markmann, James F.; Fiorina, Paolo (American Diabetes Association, 2012)
      B cells participate in the priming of the allo- and autoimmune responses, and their depletion can thus be advantageous for islet transplantation. Herein, we provide an extensive study of the effect of B-cell depletion in ...
    • Metabolomic Profiling in Individuals with a Failing Kidney Allograft 

      Bassi, Roberto; Niewczas, Monika A.; Biancone, Luigi; Bussolino, Stefania; Merugumala, Sai; Tezza, Sara; D’Addio, Francesca; Ben Nasr, Moufida; Valderrama-Vasquez, Alessandro; Usuelli, Vera; De Zan, Valentina; El Essawy, Basset; Venturini, Massimo; Secchi, Antonio; De Cobelli, Francesco; Lin, Alexander; Chandraker, Anil; Fiorina, Paolo (Public Library of Science, 2017)
      Background: Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. Methods: To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by ...
    • Near Normalization of Metabolic and Functional Features of the Central Nervous System in Type 1 Diabetic Patients With End-Stage Renal Disease After Kidney-Pancreas Transplantation 

      Fiorina, Paolo; Vezzulli, Paolo; Bassi, Roberto; Gremizzi, Chiara; Falautano, Monica; D’Addio, Francesca; Vergani, Andrea; Chabtini, Lola; Altamura, Erica; Mello, Alessandra; Caldara, Rossana; Scavini, Marina; Magnani, Giuseppe; Falini, Andrea; Secchi, Antonio (American Diabetes Association, 2012)
      OBJECTIVE The pathogenesis of brain disorders in type 1 diabetes (T1D) is multifactorial and involves the adverse effects of chronic hyperglycemia and of recurrent hypoglycemia. Kidney-pancreas (KP), but not kidney alone ...
    • Novel therapeutic and diagnostic management of heart transplant patients 

      D'Addio, Francesca; Margonato, Davide; Pensato, Umberto; Borgese, Laura; Potena, Luciano; Fiorina, Paolo (EDIMES Edizioni Internazionali Srl, 2015)
      Heart transplantation was performed for the first time 40 years ago and it is now universally considered the “gold standard” treatment for individuals suffering from end-stage heart failure. The increased understanding of ...
    • The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes 

      Azzi, Jamil; Moore, Robert F.; Elyaman, Wassim; Mounayar, Marwan; El Haddad, Najib; Yang, Sunmi; Jurewicz, Mollie; Takakura, Ayumi; Petrelli, Alessandra; Fiorina, Paolo; Ruckle, Thomas; Abdi, Reza (American Diabetes Association, 2012)
      Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, ...
    • Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report 

      Bassi, Roberto; Vergani, Andrea; D’Addio, Francesca; Nasr, Moufida Ben; Mocci, Alessio; Rastaldi, Maria Pia; Ichimura, Takaharu; Vincent Bonventre, Joseph; Fiorina, Paolo (Springer International Publishing, 2014)
      Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a ...
    • Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model 

      D’Addio, Francesca; Boenisch, Olaf; Magee, Ciara N; Yeung, Melissa; Yuan, Xueli; Mfarrej, Bechara; Vergani, Andrea; Ansari, Mohammed Javeed; Fiorina, Paolo; Najafian, Nader (Public Library of Science, 2013)
      Background: Despite significant nephrotoxicity, calcineurin inhibitors (CNIs) remain the cornerstone of immunosuppression in solid organ transplantation. We, along with others, have reported tolerogenic properties of ...
    • Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation 

      Folli, Franco; Guzzi, Valeria; Perego, Lucia; Coletta, Dawn K.; Finzi, Giovanna; Placidi, Claudia; La Rosa, Stefano; Capella, Carlo; Socci, Carlo; Lauro, Davide; Tripathy, Devjit; Jenkinson, Christopher; Paroni, Rita; Orsenigo, Elena; Cighetti, Giuliana; Gregorini, Luisa; Staudacher, Carlo; Secchi, Antonio; Bachi, Angela; Brownlee, Michael; Fiorina, Paolo (Public Library of Science, 2010)
      Background: In type 1 diabetes (T1D) vascular complications such as accelerated atherosclerosis and diffused macro-/microangiopathy are linked to chronic hyperglycemia with a mechanism that is not yet well understood. ...
    • Regenerative Therapies for Diabetic Microangiopathy 

      Bassi, Roberto; Trevisani, Alessio; Tezza, Sara; Ben Nasr, Moufida; Gatti, Francesca; Vergani, Andrea; Farina, Antonio; Fiorina, Paolo (Hindawi Publishing Corporation, 2012)
      Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose ...
    • Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes 

      Petrelli, Alessandra; Di Fenza, Raffaele; Carvello, Michele; Gatti, Francesca; Secchi, Antonio; Fiorina, Paolo (Hindawi Publishing Corporation, 2012)
      Bone-marrow-derived cells-mediated postnatal vasculogenesis has been reported as the main responsible for the regulation of vascular homeostasis in adults. Since their discovery, endothelial progenitor cells have been ...
    • Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes 

      Dada, Shirine; Wong, Masie; Law, Kenneth; Wu, Erxi; Dunussi-Joannopoulos, Kyri; Bluestone, Jeffrey; Fiorina, Paolo; Vergani, Andrea; Jurewicz, Mollie; Tian, Ze; Abdi, Reza; Guleria, Indira; Rodig, Scott J.; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to ...