Browsing by Author "Wu, Yan"
Now showing items 1-6 of 6
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Activated mouse \(CD4^+Foxp3^−\) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity
Wang, Xiaojuan; Cui, Yanyan; Luo, Gaoxing; Wang, Qinghong; Hu, Jie; He, Weifeng; Yuan, Jun; Zhou, Junyi; Wu, Yan; Sun, Xiaofeng; Robson, Simon C; Li, Xianchang; Tan, Jiangling; Peng, Yanmeng; Xue, Gang; Lu, Linrong; Gao, Wenda; Wu, Jun (Nature Publishing Group, 2012)The regulatory activities of mouse \(CD^4+Foxp3^+\) T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional \(CD4^+Foxp3^−\) T cells in the periphery are able to ... -
Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease
Longhi, Maria Serena; Moss, Alan; Bai, Aiping; Wu, Yan; Huang, Huang; Cheifetz, Adam; Quintana, Francisco J.; Robson, Simon C. (Public Library of Science, 2014)Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ... -
An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signaling
Wang, Yan; Telesford, Kiel M.; Ochoa-Repáraz, Javier; Haque-Begum, Sakhina; Christy, Marc; Kasper, Eli J.; Wang, Li; Wu, Yan; Robson, Simon C.; Kasper, Dennis L.; Kasper, Lloyd H. (2014)The mammalian immune system constitutively senses vast quantities of commensal bacteria and their products through pattern recognition receptors, yet excessive immune reactivity is prevented under homeostasis. Intestinal ... -
NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine
Bai, Aiping; Moss, Alan; Rothweiler, Sonja; Serena Longhi, Maria; Wu, Yan; Junger, Wolfgang G.; Robson, Simon C. (Nature Pub. Group, 2015)Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells to generate Tc1 cells, not only increases IFNγ production ... -
P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death
Bian, Shu; Sun, Xiaofeng; Bai, Aiping; Zhang, Chunqing; Li, Lingling; Enjoji, Keiichi; Junger, Wolfgang G; Robson, Simon Christopher; Wu, Yan (Public Library of Science, 2013)Background: Extracellular adenosine triphosphate (ATP) functions as a novel danger signal that boosts antitumor immunity and can also directly kill tumor cells. We have previously reported that chronic exposure of tumor ... -
Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer
Miao, Ruoyu; Wu, Yan; Zhang, Haohai; Zhou, Huandi; Sun, Xiaofeng; Csizmadia, Eva; He, Lian; Zhao, Yi; Jiang, Chengyu; Miksad, Rebecca A.; Ghaziani, Tahereh; Robson, Simon C.; Zhao, Haitao (Nature Publishing Group, 2016)Therapies for primary liver cancer, the third leading cause of cancer-related death worldwide, remain limited. Following multi-omics analysis (including whole genome and transcriptome sequencing), we were able to identify ...