Browsing by Author "Fiebiger, Edda"
Now showing items 1-9 of 9
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Antigen Cross-Presentation of Immune Complexes
Platzer, Barbara; Stout, Madeleine; Fiebiger, Edda (Frontiers Media S.A., 2014)The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A ... -
Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites
Platzer, Barbara; Baker, Kristi; Vera, Miguel Pinilla; Singer, Kathleen; Panduro, Marisella; Lexmond, Willem S.; Turner, Devin; Vargas, Sara O.; Kinet, Jean-Pierre; Maurer, Dieter; Baron, Rebecca M.; Blumberg, Richard S.; Fiebiger, Edda (2014)Antigen-mediated crosslinking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcεRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also ... -
Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy
Lexmond, Willem S.; Rufo, Paul A.; Fiebiger, Edda; Lencer, Wayne I. (Public Library of Science, 2015)Background and Aims Morbidity and mortality from acute diarrheal disease remains high, particularly in developing countries and in cases of natural or man-made disasters. Previous work has shown that the small molecule ... -
Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models
Mudde, Anne C. A.; Lexmond, Willem S.; Blumberg, Richard S.; Nurko, Samuel; Fiebiger, Edda (BioMed Central, 2016)Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus and commonly classified as a Th2-type allergy. Major advances in our understanding of the EoE pathophysiology have recently been made, but ... -
Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation
Bannert, Christina; Bidmon-Fliegenschnee, Bettina; Stary, Georg; Hotzy, Florian; Stift, Judith; Nurko, Samuel; Szépfalusi, Zsolt; Fiebiger, Edda; Dehlink, Eleonora (Public Library of Science, 2012)Background: The role of the high affinity IgE receptor, FcεRI, in IgE-mediated immune responses of the gastrointestinal (GI) mucosa is poorly understood. Currently, a detailed characterization of FcεRI expression throughout ... -
Relationships Between Levels of Serum IgE, Cell-Bound IgE, and IgE-Receptors on Peripheral Blood Cells in a Pediatric Population
Ratner, Adam J.; Dehlink, Eleonora; Yen, Elizabeth Hechavarria; Nurko, Samuel; Fiebiger, Edda (Public Library of Science, 2010)Background: Elevated serum immunoglobulin (Ig) E is a diagnostic marker of immediate-type allergic reactions. We hypothesize that serum IgE does not necessarily reflect total body IgE because in vivo IgE can be bound to ... -
Screen for ISG15-crossreactive Deubiquitinases
Catic, Andre; Fiebiger, Edda; Korbel, Gregory; Blom, Daniël; Galardy, Paul J.; Ploegh, Hidde L. (Public Library of Science, 2007)Background: The family of ubiquitin-like molecules (UbLs) comprises several members, each of which has sequence, structural, or functional similarity to ubiquitin. ISG15 is a homolog of ubiquitin in vertebrates and is ... -
A single glycan on IgE is indispensable for initiation of anaphylaxis
Shade, Kai-Ting C.; Platzer, Barbara; Washburn, Nathaniel; Mani, Vinidhra; Bartsch, Yannic C.; Conroy, Michelle; Pagan, Jose D.; Bosques, Carlos; Mempel, Thorsten R.; Fiebiger, Edda; Anthony, Robert M. (The Rockefeller University Press, 2015)Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental antigens, or allergens, binds and sensitizes ... -
A Soluble Form of the High Affinity IgE Receptor, Fc-Epsilon-RI, Circulates in Human Serum
Dehlink, Eleonora; Platzer, Barbara; Baker, Alexandra H.; LaRosa, Jessica; Pardo, Michael; Dwyer, Peter; Yen, Elizabeth Hechavarria; Szepfalusi, Zsolt; Nurko, Samuel; Fiebiger, Edda (Public Library of Science, 2011)Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding ...