Now showing items 1-4 of 4

    • The Microglial Sensome Revealed by Direct RNA Sequencing 

      Hickman, Suzanne E.; Kingery, Nathan D.; Ohsumi, Toshiro; Borowsky, Mark; Wang, Li-chong; Means, Terry K.; Khoury, Joseph El (2013)
      Microglia, the principal neuroimmune sentinels of the brain, continuously sense changes in their environment and respond to invading pathogens, toxins and cellular debris. Microglia exhibit plasticity and can assume ...
    • The scavenger receptor SCARF1 mediates apoptotic cell clearance and prevents autoimmunity 

      Ramirez-Ortiz, Zaida G.; Pendergraft, William F.; Prasad, Amit; Byrne, Michael H.; Iram, Tal; Blanchette, Christopher J.; Luster, Andrew D.; Hacohen, Nir; Khoury, Joseph El; Means, Terry K. (2013)
      Clearance of apoptotic cells is critical for control of tissue homeostasis however the full range of receptor(s) on phagocytes responsible for recognition of apoptotic cells remains to be identified. Here we show that ...
    • Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study 

      van Oijen, Marieke; Irizarry, Michael C.; Grodstein, Francine; Rosas, Herminia Diana; Hyman, Bradley Theodore; Growdon, John Herbert; De Vivo, Immaculata; Khoury, Joseph (Public Library of Science, 2008)
      Background: Dementia takes decades to develop, and effective prevention will likely require early intervention. Thus, it is critical to identify biomarkers of preclinical disease, allowing targeting of high-risk subjects ...
    • TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity 

      Ramirez-Ortiz, Zaida G.; Prasad, Amit; Griffith, Jason W.; Pendergraft, William F.; Cowley, Glenn S.; Root, David E.; Tai, Melissa; Luster, Andrew D.; Khoury, Joseph El; Hacohen, Nir; Means, Terry K. (2015)
      The genes and pathways that fine-tune TLR7-mediated innate inflammatory responses remain to be fully elucidated. Using an unbiased genome-scale shRNA screen, we identified the receptor TREML4 as an essential positive ...