Browsing by Author "Dirice, Ercument"

Now showing items 1-3 of 3

    • Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum 

      Teo, Adrian Kee Keong; Valdez, Ivan Achel; Dirice, Ercument; Kulkarni, Rohit N. (Elsevier, 2014)
      Summary There is considerable interest in differentiating human pluripotent stem cells (hPSCs) into definitive endoderm (DE) and pancreatic cells for in vitro disease modeling and cell replacement therapy. Numerous protocols ...

    • Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia 

      Teo, Adrian Kee Keong; Lau, Hwee Hui; Valdez, Ivan Achel; Dirice, Ercument; Tjora, Erling; Raeder, Helge; Kulkarni, Rohit N. (Elsevier, 2016)
      Summary Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully ...

    • Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes 

      Bhatt, Schweta; Gupta, Manoj; Khamaisi, Mogher; Martinez, Rachael; Gritsenko, MA; Wagner, Bridget K.; Guye, Patrick; Busskamp, Volker; Shirakawa, Jun; Wu, Gongxiong; Liew, CW; Clauss, Therese; Valdez, Ivan; El Ouaamari, Abdelfattah; Dirice, Ercument; Takatani, Tomozumi; Keenan, Hillary A.; Smith, RD; Church, George; Weiss, Ron; Wagers, Amy; Qian, Wei-Jun; King, George; Kulkarni, Rohit (Cell Press, 2015-08-04)
      The mechanisms underlying the development of complications in type 1 diabetes (T1D) are poorly understood. Disease modeling of induced pluripotent stem cells (iPSCs) from patients with longstanding T1D(disease duration ≥ ...