Now showing items 1-12 of 12

    • Activation of necroptosis in human and experimental cholestasis 

      Afonso, Marta B; Rodrigues, Pedro M; Simão, André L; Ofengeim, Dimitry; Carvalho, Tânia; Amaral, Joana D; Gaspar, Maria M; Cortez-Pinto, Helena; Castro, Rui E; Yuan, Junying; Rodrigues, Cecília M P (Nature Publishing Group, 2016)
      Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate ...
    • Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach 

      Nah, Jihoon; Yuan, Junying; Jung, Yong-Keun (Korean Society for Molecular and Cellular Biology, 2015)
      Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of ...
    • Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1 

      Py, Bénédicte F.; Jin, Mingzhi; Desai, Bimal N.; Penumaka, Anirudh; Zhu, Hong; Kober, Maike; Dietrich, Alexander; Lipinski, Marta M.; Henry, Thomas; Clapham, David E.; Yuan, Junying (2014)
      SUMMARY Caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1β (IL-1β) secretion by potentiating caspase-1 activation and induces caspase-1-independent ...
    • Cyclodepsipeptide Toxin Promotes the Degradation of Hsp90 Client Proteins through Chaperone-Mediated Autophagy 

      Shen, Shensi; Zhang, Pengtao; Lovchik, Martin A.; Li, Ying; Tang, Liuya; Chen, Zhimin; Zeng, Rong; Ma, Dawei; Yuan, Junying; Yu, Qiang (Rockefeller University Press, 2009)
      Promoting the degradation of Hsp90 client proteins by inhibiting Hsp90, an important protein chaperone, has been shown to be a promising new anticancer strategy. In this study, we show that an oxazoline analogue of apratoxin ...
    • Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death 

      Xia, Hong-guang; Najafov, Ayaz; Geng, Jiefei; Galan-Acosta, Lorena; Han, Xuemei; Guo, Yuan; Shan, Bing; Zhang, Yaoyang; Norberg, Erik; Zhang, Tao; Pan, Lifeng; Liu, Junli; Coloff, Jonathan L.; Ofengeim, Dimitry; Zhu, Hong; Wu, Kejia; Cai, Yu; Yates, John R.; Zhu, Zhengjiang; Yuan, Junying; Vakifahmetoglu-Norberg, Helin (The Rockefeller University Press, 2015)
      Hexokinase II (HK2), a key enzyme involved in glucose metabolism, is regulated by growth factor signaling and is required for initiation and maintenance of tumors. Here we show that metabolic stress triggered by perturbation ...
    • Following the Behavior of the Flagellar Rotary Motor Near Zero Load 

      Yuan, Junying; Berg, Howard (Springer Verlag, 2009)
      At room temperature at stall, the flagellar motor of the bacterium Escherichia coli exerts a torque of ~1300 pN nm. At zero external load, it spins ~330 Hz. Techniques for studying the motor near zero load are novel and ...
    • G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L 

      Zhang, Tao; Dong, Kangyun; Liang, Wei; Xu, Daichao; Xia, Hongguang; Geng, Jiefei; Najafov, Ayaz; Liu, Min; Li, Yanxia; Han, Xiaoran; Xiao, Juan; Jin, Zhenzhen; Peng, Ting; Gao, Yang; Cai, Yu; Qi, Chunting; Zhang, Qing; Sun, Anyang; Lipinski, Marta; Zhu, Hong; Xiong, Yue; Pandolfi, Pier Paolo; Li, He; Yu, Qiang; Yuan, Junying (eLife Sciences Publications, Ltd, 2015)
      Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production ...
    • Inhibition of Cell Migration by PITENINs: The Role of ARF6 

      Miao, Benchun; Skidan, Igor; Yang, Jinsheng; You, Zerong; Fu, Xueyan; Famulok, Michael; Schaffhausen, Brian; Torchilin, Vladimir; Yuan, Junying; Degterev, Alexei (Nature Publishing Group, 2012)
      We have previously reported the development of small molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show ...
    • Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis 

      Xu, Yangqing; Yuan, Junying; Lipinski, Marta M. (Landes Bioscience, 2013)
      Autophagy is induced by many cytotoxic stimuli but it is often unclear whether, under specific conditions, autophagy plays a prosurvival or a prodeath role. To answer this critical question we developed a novel methodology ...
    • Necrostatin-1 Analogues: Critical Issues on the Specificity, Activity and In Vivo Use in Experimental Disease Models 

      Takahashi, N; Duprez, L; Grootjans, S; Cauwels, A; Nerinckx, W; DuHadaway, J B; Goossens, V; Roelandt, R; Van Hauwermeiren, F; Libert, C; Declercq, W; Callewaert, N; Prendergast, G C; Degterev, A; Yuan, Junying; Vandenabeele, P (Nature Publishing Group, 2012)
      Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor ...
    • A novel role for RIP1 kinase in mediating TNFα production 

      Christofferson, D E; Li, Yan; Hitomi, J; Zhou, Wen; Upperman, C; Zhu, Hong; Gerber, S A; Gygi, Steven P.; Yuan, Junying (Nature Publishing Group, 2012)
      Receptor-interacting protein 1 (RIP1) is a Ser/Thr kinase with both kinase-dependent and kinase-independent roles in death receptor signaling. The kinase activity of RIP1 is required for necroptosis, a caspase-independent ...
    • Regulatory Interaction of the Class III PI3 Kinase Complex and p53 

      Kim, Minsu (2012-10-23)
      Autophagy is a catabolic pathway utilized by cells to maintain homeostasis. Dysregulation of this pathway often leads to various diseases, such as cancers and neurodegeneration. Therefore, autophagy must be tightly regulated ...