Browsing by Author "Weinstock, David"

Now showing items 1-8 of 8

    • Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition 

      Weigert, Oliver; Bird, Liat; Kopp, Nadja; van Bodegom, Diederik; Marubayashi, Sachie; Christie, Amanda L.; Paranal, Ronald M.; Gaul, Christoph; Vangrevelinghe, Eric; Romanet, Vincent; Murakami, Masato; Tiedt, Ralph; Ebel, Nicolas; Evrot, Emeline; De Pover, Alain; Régnier, Catherine H.; Erdmann, Dirk; Hofmann, Francesco; Levine, Ross L.; Baffert, Fabienne; Radimerski, Thomas; Lane, Andrew Alan; Chapuy, Bjoern; Toms, Angela Vivian; McKeown, Michael Robert; Bradner, James Elliott; Yoda, Akinori; Eck, Michael Joseph; Sallan, Stephen Earl; Kung, Andrew; Weinstock, David Marc (The Rockefeller University Press, 2012)
      Enzymatic inhibitors of Janus kinase 2 (JAK2) are in clinical development for the treatment of myeloproliferative neoplasms (MPNs), B cell acute lymphoblastic leukemia (B-ALL) with rearrangements of the cytokine receptor ...

    • HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia 

      Akahane, Koshi; Sanda, Takaomi; Mansour, Marc R.; Radimerski, Thomas; DeAngelo, Daniel J.; Weinstock, David M.; Look, A. Thomas (2015)
      We previously found that TYK2 tyrosine kinase signaling through its downstream effector phospho-STAT1 (p-STAT1) acts to upregulate BCL2, which in turn mediates aberrant survival of T-cell acute lymphoblastic leukemia (T-ALL) ...

    • IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells 

      Lee, Jaewoong; Robinson, Mark E.; Ma, Ning; Artadji, Dewan; Ahmed, Mohamed A.; Xiao, Gang; Sadras, Teresa; Deb, Gauri; Winchester, Janet; Cosgun, Kadriye Nehir; Geng, Huimin; Chan, Lai N.; Kume, Kohei; Miettinen, Teemu P.; Zhang, Ye; Nix, Matthew A.; Klemm, Lars; Chen, Chun Wei; Chen, Jianjun; Khairnar, Vishal; Wiita, Arun P.; Thomas-Tikhonenko, Andrei; Farzan, Michael; Jung, Jae U.; Weinstock, David; Manalis, Scott R.; Diamond, Michael S.; Vaidehi, Nagarajan; Müschen, Markus (Springer Science and Business Media LLC, 2020-11-04)
      Ifitm3 was previously identified as an endosomal protein that blocks viral infection1-3. Studying clinical cohorts of B-cell leukemia and lymphoma patients, we identified IFITM3 as a strong predictor of poor outcome. In ...

    • Mutations in G protein β subunits promote transformation and kinase inhibitor resistance 

      Yoda, Akinori; Adelmant, Guillaume; Tamburini, Jerome; Chapuy, Bjoern; Shindoh, Nobuaki; Yoda, Yuka; Weigert, Oliver; Kopp, Nadja; Wu, Shuo-Chieh; Kim, Sunhee S; Liu, Huiyun; Tivey, Trevor; Christie, Amanda L; Elpek, Kutlu G; Card, Joseph; Gritsman, Kira; Gotlib, Jason; Deininger, Michael W; Makishima, Hideki; Turley, Shannon J.; Javidi-Sharifi, Nathalie; Maciejewski, Jaroslaw P; Jaiswal, Siddhartha; Ebert, Benjamin L.; Rodig, Scott J.; Tyner, Jeffrey W; Marto, Jarrod; Weinstock, David Marc; Lane, Andrew Alan (Nature Publishing Group, 2014)
      Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ ...

    • Next-Generation cDNA Screening for Oncogene and Resistance Phenotypes 

      Shindoh, Nobuaki; Weigert, Oliver; Bird, Liat; Yoda, Akinori; Yoda, Yuka; Sullivan, Timothy J.; Lane, Andrew Alan; Kopp, Nadja; Rodig, Scott J.; Fox, Edward Alvin; Weinstock, David Marc (Public Library of Science, 2012)
      There is a pressing need for methods to define the functional relevance of genetic alterations identified by next-generation sequencing of cancer specimens. We developed new approaches to efficiently construct full-length ...

    • The p400 ATPase Regulates Nucleosome Stability and Chromatin Ubiquitination During DNA Repair 

      Xu, Ye; Sun, Yingli; Jiang, Xiaofeng; Ayrapetov, Marina; Moskwa, Patryk Pawel; Yang, Shenghong; Weinstock, David Marc; Price, Brendan D. (The Rockefeller University Press, 2010)
      The complexity of chromatin architecture presents a significant barrier to the ability of the DNA repair machinery to access and repair DNA double-strand breaks (DSBs). Consequently, remodeling of the chromatin landscape ...

    • Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 lysine 27 trimethylation 

      Lane, Andrew A.; Chapuy, Bjoern; Lin, Charles Y.; Tivey, Trevor; Li, Hubo; Townsend, Elizabeth C.; van Bodegom, Diederik; Day, Tovah A.; Wu, Shuo-Chieh; Liu, Huiyun; Yoda, Akinori; Alexe, Gabriela; Schinzel, Anna C.; Sullivan, Timothy J.; Malinge, Sébastien; Taylor, Jordan E.; Stegmaier, Kimberly; Jaffe, Jacob D.; Bustin, Michael; te Kronnie, Geertruy; Izraeli, Shai; Harris, Marian; Stevenson, Kristen E.; Neuberg, Donna; Silverman, Lewis B.; Sallan, Stephen E.; Bradner, James E.; Hahn, William C.; Crispino, John D.; Pellman, David; Weinstock, David M. (2014)
      Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-ALL)1 and polysomy 21 is the most frequent somatic aneuploidy amongst all B-ALLs2. Yet, the mechanistic links between chr.21 triplication ...

    • TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling 

      Zhong, Jun; Sharma, Jyoti; Raju, Rajesh; Palapetta, Shyam Mohan; Prasad, T. S. Keshava; Huang, Tai-Chung; Yoda, Akinori; Tyner, Jeffrey W.; van Bodegom, Diederik; Weinstock, David M.; Ziegler, Steven F.; Pandey, Akhilesh (Oxford University Press, 2014)
      Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric ...