Now showing items 1-2 of 2

    • Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 

      Tahiliani, Mamta V.; Koh, Kian Peng; Shen, Yinghua; Pastor, William Abraham; Bandukwala, Hozefa S; Brudno, Yevgeny; Agarwal, Suneet; Iyer, Lakshminarayan M.; Liu, David Ruchien; Aravind, L; Rao, Anjana (American Association for the Advancement of Science, 2009)
      DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs ...
    • Somatic coding mutations in human induced pluripotent stem cells 

      Gore, A; Li, Z; Fung, HL; Young, J; Agarwal, Suneet; Antosiewicz-Bourget, J; Canto, I; Israel, M; Kiskinis, E; Lee, JH; Loh, YH; Manos, P; Montserrat, N; Wilbert, M; Yu, J; Kirkness, E; Belmonte, JCI; Daley, GQ; Eggan, Kevin Carl; Rossi, DJ; Thomson, J; Goldstein, LSB; Zhang, K (Springer Nature, 2011)
      Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are integrated during some reprogramming methods, it is unknown whether ...