Now showing items 1-4 of 4

    • An AICD-based functional screen to identify APP metabolism regulators 

      Zhang, Can; Khandelwal, Preeti J; Chakraborty, Ranjita; Cuellar, Trinna L; Sarangi, Srikant; Patel, Shyam A; Cosentino, Christopher P; O'Connor, Michael; Lee, Jeremy C; Tanzi, Rudolph Emile; Saunders, Aleister J (BioMed Central, 2007)
      Background: A central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APP intracellular domain (AICD). ...
    • Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression 

      Li, You-Jie; Xu, Mei; Gao, Zong-Hua; Wang, Ya-Qi; Yue, Zhen; Zhang, Yan-Xia; Li, Xin-Xin; Zhang, Can; Xie, Shu-Yang; Wang, Ping-Yu (Public Library of Science, 2013)
      Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology ...
    • Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes: A meta‐analysis 

      Wang, Ping‐Yu; Fang, Jun‐Chao; Gao, Zong‐Hua; Zhang, Can; Xie, Shu‐Yang (John Wiley and Sons Inc., 2015)
      Abstract Aims/Introduction Some previous studies reported no significant association of consuming fruit or vegetables, or fruit and vegetables combined, with type 2 diabetes. Others reported that only a greater intake of ...
    • A three-dimensional human neural cell culture model of Alzheimer’s disease 

      Choi, Se Hoon; Kim, Young Hye; Hebisch, Matthias; Sliwinski, Christopher; Lee, Seungkyu; D'Avanzo, Carla; Chen, Jennifer; Hooli, Basavaraj; Asselin, Caroline; Muffat, Julien; Klee, Justin B.; Zhang, Can; Wainger, Brian Jason; Peitz, Michael; Kovacs, Dora M.; Woolf, Clifford; Wagner, Steven L.; Tanzi, Rudolph Emile; Kim, Doo Yeon (Nature Publishing Group, 2014)
      Alzheimer’s disease (AD) is the most common form of dementia, characterized by two pathological hallmarks: β-amyloid plaques and neurofibrillary tangles1. The amyloid hypothesis of AD posits that excessive accumulation of ...