Browsing by Author "Nathan, David"
Now showing items 1-14 of 14
-
Changes in Body Composition over Eight Years in a Randomized Trial of a Lifestyle Intervention: The Look AHEAD Study
Pownall, Henry J.; Bray, George A.; Wagenknecht, Lynne E.; Walkup, Michael P.; Heshka, Stanley; Hubbard, Van S.; Hill, James; Kahn, Steven E.; Nathan, David M.; Schwartz, Anne V.; Johnson, Karen C. (2014)Objective: To determine the effects of an intensive lifestyle intervention vs. a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Design and ... -
A Comparative Effectiveness Analysis of Three Continuous Glucose Monitors
Damiano, Edward R.; El-Khatib, Firas H.; Zheng, Hui; Nathan, David M.; Russell, Steven J. (American Diabetes Association, 2013)OBJECTIVE To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS Six subjects with type 1 diabetes (age 52 ± ... -
Does Glucose Variability Influence the Relationship Between Mean Plasma Glucose and \(HbA_{1c}\) Levels in Type 1 and Type 2 Diabetic Patients?
Kuenen, Judith C.; Borg, Rikke; Kuik, Dirk J.; Zheng, Zheng; Schoenfeld, David Alan; Diamant, Michaela; Nathan, David Matthew; Heine, Robert J. (American Diabetes Association, 2011)Objective: The A1C-Derived Average Glucose (ADAG) study demonstrated a linear relationship between \(HbA_{1c}\) and mean plasma glucose (MPG). As glucose variability (GV) may contribute to glycation, we examined the ... -
Effect of Glycemic Treatment and Microvascular Complications on Menopause in Women With Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort
Kim, Catherine; Cleary, Patricia A.; Cowie, Catherine C.; Braffett, Barbara H.; Dunn, Rodney L.; Larkin, Mary E.; Gatcomb, Patricia M.; Wessells, Hunter B.; Nathan, David M.; Sarma, Aruna V. (American Diabetes Association, 2014)OBJECTIVE We examined the impact of intensive versus conventional diabetes treatment upon menopause among women with type 1 diabetes in the Diabetes Control and Complications Trial (DCCT), a randomized controlled trial of ... -
Empirically Establishing Blood Glucose Targets to Achieve HbA1c Goals
Wei, Nancy; Zheng, Hui; Nathan, David M. (American Diabetes Association, 2014)OBJECTIVE To determine the average fasting, postprandial, and bedtime self-monitored blood glucose (SMBG) concentrations associated with specified HbA1c levels using data from the A1c-Derived Average Glucose (ADAG) study. ... -
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Sacks, David Barry; Arnold, Mark; Bakris, George L.; Bruns, David E.; Horvath, Andrea Rita; Kirkman, M. Sue; Lernmark, Ake; Metzger, Boyd E.; Nathan, David Matthew (American Diabetes Association, 2011)Background: Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially. Approach: An expert ... -
Levels of Oxidized LDL and Advanced Glycation End Products–Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes
Lopes-Virella, Maria F.; Virella, G.; Hunt, Kelly J.; Baker, Nathaniel L.; Lachin, John; Nathan, David Matthew; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (American Diabetes Association, 2011)OBJECTIVE High cholesterol levels in circulating immune complexes (IC), surrogate markers of modified LDL, are associated with increased carotid intima-media thickness (IMT) and cardiovascular events in type 1 diabetes. ... -
Musculoskeletal Complications in Type 1 Diabetes
Larkin, Mary E.; Barnie, Annette; Braffett, Barbara H.; Cleary, Patricia A.; Diminick, Lisa; Harth, Judy; Gatcomb, Patricia; Golden, Ellen; Lipps, Janie; Lorenzi, Gayle; Mahony, Carol; Nathan, David M. (American Diabetes Association, 2014)OBJECTIVE The development of periarticular thickening of skin on the hands and limited joint mobility (cheiroarthropathy) is associated with diabetes and can lead to significant disability. The objective of this study was ... -
Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
Eckel, Robert H.; Kahn, Steven E.; Ferrannini, Ele; Schwartz, Michael W.; Smith, Steven R.; Goldfine, Allison Braunwald; Nathan, David Matthew; Smith, Robert J. (American Diabetes Association, 2011)Objective: This report examines what is known about the relationship between obesity and type 2 diabetes and how future research in these areas might be directed to benefit prevention, interventions, and overall patient ... -
Plasma 25-Hydroxyvitamin D and Progression to Diabetes in Patients at Risk for Diabetes
Pittas, Anastassios G.; Nelson, Jason; Mitri, Joanna; Hillmann, William; Garganta, Cheryl; Nathan, David Matthew; Hu, Frank B.; Dawson-Hughes, Bess (American Diabetes Association, 2012)OBJECTIVE To investigate the association between vitamin D status, assessed by plasma 25-hydroxyvitamin D, and risk of incident diabetes. RESEARCH DESIGN AND METHODS Prospective observational study with a mean follow-up ... -
Position Statement Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Sacks, David Barry; Arnold, Mark; Bakris, George L.; Bruns, David E.; Horvath, Andrea Rita; Kirkman, M. Sue; Lernmark, Ake; Metzger, Boyd E.; Nathan, David Matthew (American Diabetes Association, 2011)Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. Approach: ... -
Pretreatment, Psychological, and Behavioral Predictors of Weight Outcomes Among Lifestyle Intervention Participants in the Diabetes Prevention Program (DPP)
Delahanty, Linda M.; Peyrot, Mark; Shrader, Peter J.; Williamson, Donald A.; Meigs, James B.; Nathan, David M. (American Diabetes Association, 2013)OBJECTIVE To identify the most important pretreatment characteristics and changes in psychological and behavioral factors that predict weight outcomes in the Diabetes Prevention Program (DPP). RESEARCH DESIGN AND METHODS ... -
Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Polak, Joseph F.; Backlund, Jye-Yu C.; Cleary, Patricia A.; Harrington, Anita P.; O’Leary, Daniel H.; Lachin, John M.; Nathan, David Matthew (American Diabetes Association, 2011)OBJECTIVE This study investigated the long-term effects of intensive diabetic treatment on the progression of atherosclerosis, measured as common carotid artery intima-media thickness (IMT). RESEARCH DESIGN AND METHODS ... -
Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes
Faustman, Denise Louise; Wang, Limei; Okubo, Yoshiaki; Burger, Douglas E.; Ban, Liqin; Man, Guotong; Zheng, Hui; Schoenfeld, David Alan; Pompei, Richard; Avruch, Joseph; Nathan, David Matthew (Public Library of Science, 2012)Background: No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it ...