Now showing items 1-7 of 7

    • Antiretroviral dynamics determines HIV evolution and predicts therapy outcome 

      Rosenbloom, Daniel Scholes; Hill, Alison Lynn; Rabi, S. Alireza; Siliciano, Robert F.; Nowak, Martin A. (Nature Publishing Group, 2012)
      Despite the high inhibition of viral replication achieved by current anti-HIV drugs, many patients fail treatment, often with emergence of drug-resistant virus. Clinical observations show that the relationship between ...
    • Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1 

      Rosenbloom, Daniel I. S.; Elliott, Oliver; Hill, Alison L.; Henrich, Timothy J.; Siliciano, Janet M.; Siliciano, Robert F. (Oxford University Press, 2015)
      Limiting dilution assays are widely used in infectious disease research. These assays are crucial for current human immunodeficiency virus (HIV)-1 cure research in particular. In this study, we offer new tools to help ...
    • Dynamics of HIV treatment and social contagion 

      Hill, Alison Lynn (2013-10-08)
      Modern-day management of infectious diseases is critically linked to the use of mathematical models to understand and predict dynamics at many levels, from the mechanisms of pathogenesis to the patterns of population-wide ...
    • Emotions as infectious diseases in a large social network: the SISa model 

      Hill, Alison Lynn; Rand, David Gertler; Nowak, Martin A.; Christakis, N (The Royal Society, 2010)
      Human populations are arranged in social networks that determine interactions and influence the spread of diseases, behaviours and ideas. We evaluate the spread of long-term emotional states across a social network. We ...
    • Infectious Disease Modeling of Social Contagion in Networks 

      Hill, Alison Lynn; Rand, David Gertler; Nowak, Martin A.; Christakis, Nicholas Alexander (Public Library of Science, 2010)
      Many behavioral phenomena have been found to spread interpersonally through social networks, in a manner similar to infectious diseases. An important difference between social contagion and traditional infectious diseases, ...
    • Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV 

      Hill, Alison L.; Rosenbloom, Daniel I. S.; Goldstein, Edward; Hanhauser, Emily; Kuritzkes, Daniel R.; Siliciano, Robert F.; Henrich, Timothy J. (Public Library of Science, 2016)
      Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are ...
    • Silicon Nanoparticles as Hyperpolarized Magnetic Resonance Imaging Agents 

      Aptekar, Jacob W.; Cassidy, Maja Clare; Johnson, Alexander C.; Barton, Robert A.; Lee, Menyoung; Ogier, Alexander C.; Vo, Chinh; Anahtar, Melis Nuray; Yin, Ren; Bhatia, Sangeeta; Ramanathan, Chandrasekhar; Cory, David G.; Hill, Alison Lynn; Mair, Ross W.; Rosen, Matthew Scot; Walsworth, Ronald L.; Marcus, Charles Masamed (American Chemical Society, 2009)
      Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear ...