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    • Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data 

      Macalalad, Alexander R.; Zody, Michael; Charlebois, Patrick; Lennon, Niall J.; Newman, Ruchi M.; Malboeuf, Christine M.; Ryan, Elizabeth Marie; Boutwell, Christian Lane; Power, Karen A.; Brackney, Doug E.; Pesko, Kendra N.; Levin, Joshua Zvi; Ebel, Gregory D.; Allen, Todd; Birren, Bruce W.; Henn, Matthew R. (Public Library of Science, 2012)
      Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral ...