Browsing by Author "Chou, David"

Now showing items 1-3 of 3

    • On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology 

      Chou, David; Frismantas, Viktoras; Milton, Yuka; David, Rhiannon; Pop-Damkov, Petar; Ferguson, Douglas; MacDonald, Alexander; Vargel Bolukbasi, Ozge; Joyce, Cailin E.; Moreira Teixeira, Liliana S.; Rech, Arianna; Jiang, Amanda; Calamari, Elizabeth; Jalili-Firoozinezhad, Sasan; Furlong, Brooke; O’Sullivan, Lucy R.; Ng, Carlos F.; Choe, Youngjae; Marquez, Susan; Myers, Kasiani C.; Weinberg, Olga K.; Hasserjian, Robert; Novak, Richard; Levy, Oren; Prantil-Baun, Rachelle; Novina, Carl; Shimamura, Akiko; Ewart, Lorna; Ingber, Donald (Springer Science and Business Media LLC, 2020-01-27)
      The inaccessibility of living bone marrow hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human bone-marrow-on-a-chip ...

    • Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips 

      Herland, Anna; Maoz, Ben M.; Das, Debarun; Somayaji, Mahadevabharath R.; Prantil-Baun, Rachelle; Novak, Richard; Cronce, Michael; Huffstater, Tessa; Jeanty, Sauveur S.F.; Ingram, Miles; Chalkiadaki, Angeliki; Chou, David; Clauson, Susan; Delahanty, Aaron; Jalili-Firoozinezhad, Sasan; Milton, Yuka; Sontheimer-Phelps, Alexandra; Swenor, Ben; Levy, Oren; Parker, Kevin K.; Przekwas, Andrzej; Ingber, Donald (Springer Science and Business Media LLC, 2020-01-27)
      Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. ...

    • Robotic fluidic coupling and interrogation of multiple vascularized organ chips 

      Novak, Richard; Ingram, Miles; Marquez, Susan; Das, Debarun; Delahanty, Aaron; Herland, Anna; Maoz, Ben; Jeanty, Sauveur; Somayaji, Mahadevabharath R.; Burt, Morgan; Calamari, Elizabeth; Chalkiadaki, Angeliki; Cho, Alexander; Choe, Youngjae; Chou, David; Cronce, Michael; Dauth, Stephanie; Divic, Toni; Fernandez-Alcon, Jose; Ferrante, Thomas; Ferrier, John; FitzGerald, Edward; Fleming, Rachel; Jalili Firoozinezhad, Sasan; Grevesse, Thomas; Goss, Josue; Hamkins-Indik, Tiama; Henry, Olivier; Hinojosa, Chris; Huffstater, Tessa; Jang, Kyung-Jin; Kujala, Ville; Leng, Lian; Mannix, Robert; Milton, Yuka; Nawroth, Janna; Nestor, Bret; Ng Pitti, Carlos; O'Connor, Blakely; Park, Tae-Eun; Sanchez, Henry; Sliz, Josiah; Sontheimer-Phelps, Alexandra; Swenor, Ben; Thompson, Guy; Touloumes, George J.; Tranchemontagne, Zachary; Wen, Norman; Yedid, Moran; Bahinski, Anthony; Hamilton, Geraldine; Levner, Daniel; Levy, Oren; Przekwas, Andrzej; Prantil-Baun, Rachelle; Parker, Kevin; Ingber, Donald (Springer Science and Business Media LLC, 2020-01-27)
      Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an ‘Interrogator’ employing ...