Now showing items 1-5 of 5

    • Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity 

      Bartelt, Alexander; Widenmaier, Scott Bradley; Schlein, Christian; Johann, Kornelia; Goncalves, Renata L.S.; Eguchi, Kosei; Fischer, Alexander W; Parlakgul, Gunes; Snyder, Nicole; Nguyen, Truc B; Bruns, Oliver T; Franke, Daniel; Bawendi, Moungi G; Lynes, Matthew David; Leiria, Luiz O; Tseng, Yu-Hua; Inouye, Karen; Arruda, Ana Paula; Hotamisligil, Gokhan S. (Springer Nature, 2018)
      Objective Brown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet‐induced thermogenesis ...
    • Chronic enrichment of hepatic ER-mitochondria contact sites leads to calcium dependent mitochondrial dysfunction in obesity 

      Arruda, Ana Paula; Pers, Benedicte Mengel; Parlakgül, Güneş; Güney, Ekin; Inouye, Karen; Hotamisligil, Gökhan S. (2015)
      Proper function of the endoplasmic reticulum (ER) and mitochondria is critical for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states including metabolic diseases. Although ...
    • A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization 

      Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)
      Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...
    • Novel role of PKR in inflammasome activation and HMGB1 release 

      Lu, Ben; Nakamura, Takahisa; Inouye, Karen; Li, Jianhua; Tang, Yiting; Lundbäck, Peter; Valdes-Ferrer, Sergio I; Olofsson, Peder S.; Kalb, Thomas; Roth, Jesse; Zou, Yongrui; Erlandsson-Harris, Helena; Yang, Huan; Ting, Jenny P-Y; Wang, Haichao; Andersson, Ulf; Antoine, Daniel J.; Chavan, Sangeeta S.; Hotamisligil, Gökhan S.; Tracey, Kevin J. (2014)
      The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an ...
    • Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins 

      Charles, Khanichi N.; Li, Min-Dian; Engin, Feyza; Arruda, Ana Paula; Inouye, Karen; Hotamisligil, Gokhan S. (Elsevier BV, 2017)
      Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) ...