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    • Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening 

      Menon, Usha; Ryan, Andy; Kalsi, Jatinderpal; Gentry-Maharaj, Aleksandra; Dawnay, Anne; Habib, Mariam; Apostolidou, Sophia; Singh, Naveena; Benjamin, Elizabeth; Burnell, Matthew; Davies, Susan; Sharma, Aarti; Gunu, Richard; Godfrey, Keith; Lopes, Alberto; Oram, David; Herod, Jonathan; Williamson, Karin; Seif, Mourad W.; Jenkins, Howard; Mould, Tim; Woolas, Robert; Murdoch, John B.; Dobbs, Stephen; Amso, Nazar N.; Leeson, Simon; Cruickshank, Derek; Scott, Ian; Fallowfield, Lesley; Widschwendter, Martin; Reynolds, Karina; McGuire, Alistair; Campbell, Stuart; Parmar, Mahesh; Skates, Steven J.; Jacobs, Ian (American Society of Clinical Oncology, 2015)
      Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection ...