Browsing by Author "Silberstein, Leslie"
Now showing items 1-12 of 12
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Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination
Jo, Hakryul; Lo, Pang-Kuo; Li, Yitang; Loison, Fabien; Green, Sarah; Wang, Jake; Silberstein, Leslie E.; Ye, Keqiang; Chen, Hexin; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2011)The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, ... -
Deficiency of Lipid Phosphatase SHIP Enables Long-Term Reconstitution of Hematopoietic Inductive Bone Marrow Microenvironment
Liang, Olin Dehui; Lu, Jiayun; Nombela-Arrieta, César; Zhong, Jia; Zhao, Li; Pivarnik, Gregory; Mondal, Subhanjan; Chai, Li; Silberstein, Leslie E.; Luo, Hongbo (Elsevier BV, 2013)A dysfunctional bone marrow (BM) microenvironment is thought to contribute to the development of hematologic diseases. However, functional replacement of pathologic BM microenvironment through BM transplantation has not ... -
Fak Depletion in Both Hematopoietic and Nonhematopoietic Niche Cells Leads to Hematopoietic Stem Cell Expansion
Lu, Jiayun; Sun, Yan; Nombela-Arrieta, Cesar; Du, Karrie P.; Park, Shin-Young; Chai, Li; Walkley, Carl; Luo, Hongbo; Silberstein, Leslie E. (Elsevier BV, 2012)Hematopoietic stem cells (HSCs) reside in complex bone marrow microenvironments, where niche-induced signals regulate hematopoiesis. Focal adhesion kinase (Fak) is a nonreceptor protein tyrosine kinase that plays an essential ... -
Fgd5 identifies hematopoietic stem cells in the murine bone marrow
Gazit, Roi; Mandal, Pankaj K.; Ebina, Wataru; Ben-Zvi, Ayal; Nombela-Arrieta, César; Silberstein, Leslie E.; Rossi, Derrick J. (The Rockefeller University Press, 2014)Hematopoietic stem cells (HSCs) are the best-characterized tissue-specific stem cells, yet experimental study of HSCs remains challenging, as they are exceedingly rare and methods to purify them are cumbersome. Moreover, ... -
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating both Adhesion-Dependent and -Independent Cellular Signals
Kasorn, Anongnard; Alcaide, Pilar; Jia, Yonghui; Subramanian, Kulandayan K.; Sarraj, Bara; Li, Yitang; Loison, Fabien; Hattori, Hidenori; Silberstein, Leslie E.; Luscinskas, William F.; Luo, Hongbo (American Association of Immunologists, 2009)Various neutrophil functions such as phagocytosis, superoxide production, and survival are regulated by integrin signaling. Despite the essential role of focal adhesion kinase (FAK) in mediating this signaling pathway, its ... -
Inositol Trisphosphate 3-Kinase B (InsP3KB) as a Physiological Modulator of Myelopoiesis
Jia, Yonghui; Loison, Fabien; Hattori, Hidenori; Li, Yitang; Erneux, Christophe; Park, Shin-Young; Gao, Chong; Chai, Li; Silberstein, Leslie E.; Schurmans, Stephane; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2008)Inositol trisphosphate 3-kinase B (InsP3KB) belongs to a family of kinases that convert inositol 1,4,5-trisphosphate (Ins(1,4,5)P3 or IP3) to inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). Previous studies have shown ... -
Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation
Sarraj, Bara; Massberg, Steffen; Li, Yitang; Kasorn, Anongnard; Subramanian, Kulandayan; Loison, Fabien; Silberstein, Leslie E.; von Andrian, Ulrich H.; Luo, Hongbo (American Association of Immunologists, 2014-11-04)Phosphatidylinositol 3,4,5-trisphosphate \((PIP_3)\) is a second messenger that is involved in a number of cell activities including cell growth, proliferation, and motility. \(PIP_3\) is produced by PI3K and regulated by ... -
Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs
Jo, Hakryul; Loison, Fabien Xavier; Hattori, Hidenori; Silberstein, Leslie E.; Yu, Hongtao; Luo, Hongbo (Public Library of Science, 2010)Background: Microtubule drugs are effective anti-cancer agents, primarily due to their ability to induce mitotic arrest and subsequent cell death. However, some cancer cells are intrinsically resistant or acquire a resistance. ... -
Pretreatment with Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibitor SF1670 Augments the Efficacy of Granulocyte Transfusion in a Clinically Relevant Mouse Model
Li, Yitang; Prasad, Amit; Jia, Yonghui; Roy, Saurabh Ghosh; Loison, Fabien; Mondal, Subhanjan; Kocjan, Paulina; Silberstein, Leslie E.; Ding, Sheng; Luo, Hongbo (American Society of Hematology, 2011)The clinical outcome of granulocyte transfusion therapy is often hampered by short ex vivo shelf life, inefficiency of recruitment to sites of inflammation, and poor pathogen-killing capability of transplanted neutrophils. ... -
Relevant Mouse Model for Human Monocytic Leukemia through Cre/lox-Controlled Myeloid-Specific Deletion of PTEN
Yu, H.; Li, Yili; Gao, Chuanyun; Fabien, L.; Jia, Y.; Lu, Junjie; Silberstein, Leslie E.; Pinkus, Geraldine Sowinski; Ye, K.; Chai, Li; Luo, Hongbo (Nature Publishing Group, 2010) -
SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway during B Lymphopoiesis
Le, Yi; Zhu, Bing-Mei; Harley, Brendan; Park, Shin-Young; Kobayashi, Takashi; Manis, John P.; Luo, Hongbo; Yoshimura, Akihiko; Hennighausen, Lothar; Silberstein, Leslie E. (Elsevier BV, 2007)The chemokine CXCL12 induces prolonged focal adhesion kinase (FAK) phosphorylation and sustained proadhesive responses in progenitor bone-marrow (BM) B cells, but not in mature peripheral B cells. Here we demonstrate that ... -
Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
Lu, Jiayun; Kong, Nikki; Carroll, John; Capogrossi, Maurizio; Jeong, Ha-Won; Yang, Yang; Luo, Hongbo; Silberstein, Leslie E.; Chai, Li; Ma, Yupo (Public Library of Science, 2009)Background The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both development and leukemogenesis. It is a unique gene that is involved in self-renewal in ESC and leukemic stem cell (LSC).Methodology/Principal ...