Now showing items 1-5 of 5

    • CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation 

      Hayakawa, Kazuhide; Pham, Loc-Duyen; Seo, Ji-Hae; Miyamoto, Nobukazu; Maki, Takakuni; Sakadzic, Sava; Boas, David A.; van Leyen, Klaus J.; Waeber, Christian; Kim, Kyu-Won; Arai, Ken; Lo, Eng H. (SAGE Publications, 2016)
      There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ...
    • Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy 

      Jiang, Yinghua; Fan, Xiang; Yu, Zhanyang; Liao, Zhengbu; Wang, Xiao-Shu; van Leyen, Klaus; Sun, Xiaochuan; Lo, Eng H.; Wang, Xiaoying (Frontiers Media S.A., 2015)
      Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA ...
    • Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice 

      Foerch, Christian; Rosidi, Nathanael L.; Schlunk, Frieder; Lauer, Arne; Cianchetti, Flor A.; Mandeville, Emiri T; Arai, Ken; Yigitkanli, Kazim; Fan, Xiang; Wang, Xiaoying; van Leyen, Klaus J.; Steinmetz, Helmuth; Schaffer, Chris B.; Lo, Eng H. (Public Library of Science, 2013)
      Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral ...
    • Non-Invasive Monitoring of Chronic Liver Disease via Near-Infrared and Shortwave-Infrared Imaging of Endogenous Lipofuscin 

      Saif, Mari; Kwanten, Wilhelmus J.; Carr, Jessica A.; Chen, Ivy X.; Posada, Jessica; Srivastava, Amitabh; Zhang, Juanye; Zheng, Yi; Pinter, Matthias; Chatterjee, Sampurna; Softic, Samir; Kahn, C.; van Leyen, Klaus; Bruns, Oliver T.; Jain, Rakesh; Bawendi, Moungi G. (Springer Science and Business Media LLC, 2020-08)
      Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and ...
    • STAT-Dependent Upregulation of 12/15-Lipoxygenase Contributes to Neuronal Injury after Stroke 

      Jung, Joo Eun; Karatas, Hulya; Liu, Yu; Yalcin, Ayfer; Montaner, Joan; Lo, Eng H.; van Leyen, Klaus J. (SAGE Publications, 2015)
      Oxidative stress is a major brain injury mechanism following ischemic stroke. 12/15-lipoxygenase (12/15-LOX) is a key mediator of oxidative stress, contributing to neuronal cell death and vascular leakage. Nonetheless, the ...