Browsing by Author "Holt, Daphne"
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Abnormalities in personal space and parietal–frontal function in schizophrenia
Holt, Daphne J.; Boeke, Emily A.; Coombs, Garth; DeCross, Stephanie N.; Cassidy, Brittany S.; Stufflebeam, Steven; Rauch, Scott L.; Tootell, Roger B.H. (Elsevier, 2015)Schizophrenia is associated with subtle abnormalities in day-to-day social behaviors, including a tendency in some patients to “keep their distance” from others in physical space. The neural basis of this abnormality, and ... -
Amygdala Perfusion Is Predicted by Its Functional Connectivity with the Ventromedial Prefrontal Cortex and Negative Affect
Coombs III, Garth; Loggia, Marco L.; Greve, Douglas N.; Holt, Daphne J. (Public Library of Science, 2014)Background: Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction ... -
Factors that distinguish college students with depressive symptoms with and without suicidal thoughts
Nyer, Maren Bess; Holt, Daphne Jane; Pedrelli, Paola; Fava, Maurizio; Ameral, Victoria; Cassiello, Clair F.; Nock, Matthew K.; Ross, Margaret; Hutchinson, Dori; Farabaugh, Amy (Springer, 2013)BACKGROUND Suicide among college students is a significant public health concern. Although suicidality is linked to depression, not all depressed college students experience suicidal ideation (SI). The primary aim of ... -
In Vivo Imaging of Adult Human Hippocampal Neurogenesis: Progress, Pitfalls and Promise
Ho, N F; Hooker, Jacob M; Sahay, Amar; Holt, Daphne Jane; Roffman, Joshua Lawrence (Springer Nature, 2013)New neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we ... -
A parametric study of fear generalization to faces and non-face objects: relationship to discrimination thresholds
Holt, Daphne J.; Boeke, Emily A.; Wolthusen, Rick P. F.; Nasr, Shahin; Milad, Mohammed R.; Tootell, Roger B. H. (Frontiers Media S.A., 2014)Fear generalization is the production of fear responses to a stimulus that is similar—but not identical—to a threatening stimulus. Although prior studies have found that fear generalization magnitudes are qualitatively ... -
Parcellating Cortical Functional Networks in Individuals
Wang, Danhong; Buckner, Randy L.; Fox, Michael D.; Holt, Daphne J.; Holmes, Avram J.; Stoecklein, Sophia; Langs, Georg; Pan, Ruiqi; Qian, Tianyi; Li, Kuncheng; Baker, Justin T.; Stufflebeam, Steven M.; Wang, Kai; Wang, Xiaomin; Hong, Bo; Liu, Hesheng (2015)The capacity to identify the unique functional architecture of an individual’s brain is a critical step towards personalized medicine and understanding the neural basis of variations in human cognition and behavior. Here, ... -
Progression from selective to general involvement of hippocampal subfields in schizophrenia
Ho, New Fei; Iglesias, Juan Eugenio; Sum, Min Yi; Kuswanto, Carissa Nadia; Sitoh, Yih Yian; De Souza, Joshua; Hong, Zhaoping; Fischl, Bruce; Roffman, Joshua L.; Zhou, Juan; Sim, Kang; Holt, Daphne J. (2016)Volume deficits of the hippocampus in schizophrenia have been consistently reported. However, the hippocampus is anatomically heterogeneous; it remains unclear whether certain portions of the hippocampus are affected more ... -
Sex Differences in the Neurobiology of Fear Conditioning and Extinction: A Preliminary fMRI Study of Shared Sex Differences with Stress-Arousal Circuitry
Lebron-Milad, Kelimer; Milad, Mohammed Ragib; Abbs, Brandon R.; Linnman, Clas; Rougemount-Bücking, Ansgar; Zeidan, Mohammed A.; Holt, Daphne J.; Goldstein, Jill M. (BioMed Central, 2012)Background: The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning and extinction, and are brain regions known to be sexually dimorphic. We used functional ...