Now showing items 1-8 of 8

    • Abnormalities in personal space and parietal–frontal function in schizophrenia 

      Holt, Daphne J.; Boeke, Emily A.; Coombs, Garth; DeCross, Stephanie N.; Cassidy, Brittany S.; Stufflebeam, Steven; Rauch, Scott L.; Tootell, Roger B.H. (Elsevier, 2015)
      Schizophrenia is associated with subtle abnormalities in day-to-day social behaviors, including a tendency in some patients to “keep their distance” from others in physical space. The neural basis of this abnormality, and ...
    • Amygdala Perfusion Is Predicted by Its Functional Connectivity with the Ventromedial Prefrontal Cortex and Negative Affect 

      Coombs III, Garth; Loggia, Marco L.; Greve, Douglas N.; Holt, Daphne J. (Public Library of Science, 2014)
      Background: Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction ...
    • Factors that distinguish college students with depressive symptoms with and without suicidal thoughts 

      Nyer, Maren Bess; Holt, Daphne Jane; Pedrelli, Paola; Fava, Maurizio; Ameral, Victoria; Cassiello, Clair F.; Nock, Matthew K.; Ross, Margaret; Hutchinson, Dori; Farabaugh, Amy (Springer, 2013)
      BACKGROUND Suicide among college students is a significant public health concern. Although suicidality is linked to depression, not all depressed college students experience suicidal ideation (SI). The primary aim of ...
    • In Vivo Imaging of Adult Human Hippocampal Neurogenesis: Progress, Pitfalls and Promise 

      Ho, N F; Hooker, Jacob M; Sahay, Amar; Holt, Daphne Jane; Roffman, Joshua Lawrence (Springer Nature, 2013)
      New neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we ...
    • A parametric study of fear generalization to faces and non-face objects: relationship to discrimination thresholds 

      Holt, Daphne J.; Boeke, Emily A.; Wolthusen, Rick P. F.; Nasr, Shahin; Milad, Mohammed R.; Tootell, Roger B. H. (Frontiers Media S.A., 2014)
      Fear generalization is the production of fear responses to a stimulus that is similar—but not identical—to a threatening stimulus. Although prior studies have found that fear generalization magnitudes are qualitatively ...
    • Parcellating Cortical Functional Networks in Individuals 

      Wang, Danhong; Buckner, Randy L.; Fox, Michael D.; Holt, Daphne J.; Holmes, Avram J.; Stoecklein, Sophia; Langs, Georg; Pan, Ruiqi; Qian, Tianyi; Li, Kuncheng; Baker, Justin T.; Stufflebeam, Steven M.; Wang, Kai; Wang, Xiaomin; Hong, Bo; Liu, Hesheng (2015)
      The capacity to identify the unique functional architecture of an individual’s brain is a critical step towards personalized medicine and understanding the neural basis of variations in human cognition and behavior. Here, ...
    • Progression from selective to general involvement of hippocampal subfields in schizophrenia 

      Ho, New Fei; Iglesias, Juan Eugenio; Sum, Min Yi; Kuswanto, Carissa Nadia; Sitoh, Yih Yian; De Souza, Joshua; Hong, Zhaoping; Fischl, Bruce; Roffman, Joshua L.; Zhou, Juan; Sim, Kang; Holt, Daphne J. (2016)
      Volume deficits of the hippocampus in schizophrenia have been consistently reported. However, the hippocampus is anatomically heterogeneous; it remains unclear whether certain portions of the hippocampus are affected more ...
    • Sex Differences in the Neurobiology of Fear Conditioning and Extinction: A Preliminary fMRI Study of Shared Sex Differences with Stress-Arousal Circuitry 

      Lebron-Milad, Kelimer; Milad, Mohammed Ragib; Abbs, Brandon R.; Linnman, Clas; Rougemount-Bücking, Ansgar; Zeidan, Mohammed A.; Holt, Daphne J.; Goldstein, Jill M. (BioMed Central, 2012)
      Background: The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning and extinction, and are brain regions known to be sexually dimorphic. We used functional ...