Browsing by Author "Muehlschlegel, Jochen"

Now showing items 1-12 of 12

    • Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia 

      Sigurdsson, Martin I.; Saddic, Louis; Heydarpour, Mahyar; Chang, Tzuu-Wang; Shekar, Prem; Aranki, Sary; Couper, Gregory S.; Shernan, Stanton K.; Seidman, Jon G.; Body, Simon C.; Muehlschlegel, Jochen D. (BioMed Central, 2016)
      Background: Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from ...

    • Association between bicuspid aortic valve morphotype and regional dilatation of the aortic root and trunk 

      Habchi, Karam M.; undefined, undefined; Ashikhmina, Elena; Vieira, Vanessa Montiero; Shahram, Jasmin T.; Isselbacher, Eric Michael; Sundt, Thoralf M; Shekar, Prem; Muehlschlegel, Jochen Daniel; Body, Simon Christopher (Springer Nature, 2016)
      Thoracic aortic disease, including thoracic aor- tic aneurysm (TAA), is frequently seen in patients with bicuspid aortic valve (BAV). We hypothesized that BAV morphotype would be associated with aortic aneurysm phe- notypes ...

    • Blood volume measurement by hemodilution: association with valve disease and re-evaluation of the Allen Formula 

      Hilberath, JN; Thomas, Megha Elizabeth; Smith, T; Jara, C; Fitzgerald, DJ; Wilusz, K; Liu, X; Muehlschlegel, Jochen Daniel (SAGE Publications, 2014)
      Background: Total blood volume (TBV) assessment is central to the management of cardiac surgical patients with cardiopulmonary bypass (CPB). The widely accepted Allen Formula lacks accuracy in estimating TBV in these ...

    • Blood volumes in cardiac surgery with cardiopulmonary bypass 

      Hilberath, JN; Smith, T; Jara, C; Thomas, M; FitzGerald, DJ; Muehlschlegel, Jochen Daniel (SAGE Publications, 2014)
      Purpose: Total blood volume (TBV) estimation potentially impacts various aspects of cardiac surgical care, including pharmacological and transfusion interventions, hemodynamic and volume management and perfusion equipment ...

    • C-Reactive Protein Gene Variants Are Associated with Postoperative C-reactive Protein Levels After Coronary Artery Bypass Surgery 

      Perry, Tjörvi E; Muehlschlegel, Jochen Daniel; Liu, Kuang-Yu; Fox, Amanda Arlene; Collard, Charles D; Body, Simon Christopher; Shernan, Stanton K. (BioMed Central, 2009)
      Background: Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ...

    • Duration of Postoperative Atrial Fibrillation After Cardiac Surgery Is Associated With Worsened Long-Term Survival 

      Sigurdsson, Martin I.; Longford, Nicholas T.; Heydarpour, Mahyar; Saddic, Louis; Chang, Tzuu-Wang; Fox, Amanda A.; Collard, Charles D.; Aranki, Sary Fouad; Shekar, Prem; Shernan, Stanton K.; Muehlschlegel, Jochen Daniel; Body, Simon Christopher (Elsevier BV, 2016)
      Background. Studies of the effects of postoperative atrial fibrillation (poAF) on long-term survival are con- flicting, likely because of comorbidities that occur with poAF and the patient populations studied. Furthermore, ...

    • Genetic and Clinical Risk Prediction Model for Postoperative Atrial Fibrillation 

      Kolek, M. J.; Muehlschlegel, Jochen Daniel; Bush, W. S.; Parvez, B.; Murray, K. T.; Stein, C. M.; Shoemaker, M. B.; Blair, M. A.; Kor, K. C.; Roden, D. M.; Donahue, B. S.; Fox, A. A.; Shernan, S. K.; Collard, C. D.; Body, Simon Christopher; Darbar, D. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome ...

    • Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery 

      Leaf, David Evan; Body, Simon Christopher; Muehlschlegel, Jochen Daniel; McMahon, Gearoid; Lichtner, P.; Collard, C. D.; Shernan, S. K.; Fox, A. A.; Waikar, Sushrut Subhash (American Society of Nephrology (ASN), 2016)
      Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, which may be involved in the pathogenesis of AKI. Length polymorphisms in the number of GT dinucleotide repeats in the HO-1 gene (HMOX1) promoter inversely associate ...

    • The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle 

      Saddic, Louis A.; Sigurdsson, Martin I.; Chang, Tzuu-Wang; Mazaika, Erica; Heydarpour, Mahyar; Shernan, Stanton K.; Seidman, Christine Edry; Seidman, Jonathan G.; Aranki, Sary Fouad; Body, Simon Christopher; Muehlschlegel, Jochen Daniel (Ovid Technologies (Wolters Kluwer Health), 2017)
      Background—The discovery of functional classes of long noncoding RNAs (lncRNAs) has expanded our understanding of the variety of RNA species that exist in cells. In the heart, lncRNAs have been implicated in the regulation ...

    • Noteworthy Articles in 2015 for the Cardiothoracic Anesthesiologist 

      Varelmann, Dirk; Muehlschlegel, Jochen Daniel (SAGE Publications, 2016)
      Large multicenter, randomized controlled trials published in reputable journals had a large impact on the world of cardiothoracic anesthesia in 2015. We as cardiac anesthesiologists pride ourselves as being experts in ...

    • Perioperative genomics: coming soon to (operating) theatres near you 

      Sigurdsson, Martin I.; Muehlschlegel, Jochen Daniel (Springer Nature, 2015)

    • Plasma Corin Decreases After Coronary Artery Bypass Graft Surgery and Is Associated With Postoperative Heart Failure: A Pilot Study 

      Barnet, Caryn S.; Liu, Xiaoxiao; Body, Simon Christopher; Collard, Charles D.; Shernan, Stanton K.; Muehlschlegel, Jochen Daniel; Jarolim, Petr; Fox, Amanda A. (Elsevier BV, 2015)
      Objective: Corin is a natriuretic peptide-converting enzyme that cleaves precursor pro-B-type natriuretic peptide to active B-type natriuretic peptide (BNP) (diuretic, natriuretic, and vaso- dilatory properties). Increased ...