Browsing by Author "Shapiro, Nathan"

Now showing items 1-11 of 11

    • The Association of Near-Infrared Spectroscopy-Derived Tissue Oxygenation Measurements with Sepsis Syndromes, Organ Dysfunction and Mortality in Emergency Department Patients with Sepsis 

      Arnold, Ryan; Sherwin, Robert; O'Connor, Jennifer; Najarro, Gabriel; Lundy, David; Nelson, Teresa; Shapiro, Nathan Ivan; Singh, Sam; Trzeciak, Stephen W.; Jones, Alan E.; Emergency Medicine Shock Research Network (BioMed Central, 2011)
      Introduction: Near-infrared spectroscopy (NIRS) noninvasively measures peripheral tissue oxygen saturation \((StO_2)\). NIRS may be utilized along with a vascular occlusion test, in which limb blood flow is temporarily ...

    • Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach 

      Skibsted, Simon; Bhasin, Manoj K; Aird, William C; Shapiro, Nathan I (BioMed Central, 2013)
      The early, accurate diagnosis and risk stratification of sepsis remains an important challenge in the critically ill. Since traditional biomarker strategies have not yielded a gold standard marker for sepsis, focus is ...

    • A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood 

      Cartwright, Mark; Rottman, Martin; Shapiro, Nathan I.; Seiler, Benjamin; Lombardo, Patrick; Gamini, Nazita; Tomolonis, Julie; Watters, Alexander L.; Waterhouse, Anna; Leslie, Dan; Bolgen, Dana; Graveline, Amanda; Kang, Joo H.; Didar, Tohid; Dimitrakakis, Nikolaos; Cartwright, David; Super, Michael; Ingber, Donald E. (Elsevier, 2016)
      Background: Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a rapid test that can diagnose ...

    • Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis 

      Hou, Peter C.; Filbin, Michael R.; Napoli, Anthony; Feldman, Joseph; Pang, Peter S.; Sankoff, Jeffrey; Lo, Bruce M.; Dickey-White, Howard; Birkhahn, Robert H.; Shapiro, Nathan I. (Lippincott Williams & Wilkins, 2016)
      ABSTRACT Objective: Fluid responsiveness is proposed as a physiology-based method to titrate fluid therapy based on preload dependence. The objectives of this study were to determine if a fluid responsiveness protocol would ...

    • Diabetes and Sepsis: Preclinical Findings and Clinical Relevance 

      Schuetz, Philipp; Castro, Pedro; Shapiro, Nathan Ivan (American Diabetes Association, 2011)

    • A guide to human in vivo microcirculatory flow image analysis 

      Massey, Michael J.; Shapiro, Nathan I. (BioMed Central, 2016)
      Various noninvasive microscopic camera technologies have been used to visualize the sublingual microcirculation in patients. We describe a comprehensive approach to bedside in vivo sublingual microcirculation video image ...

    • Metal-Amplified Density Assays, (MADAs), including a Density-Linked Immunosorbent Assay (DeLISA) 

      Subramaniam, Anand; Gonidec, Mathieu; Shapiro, Nathan Ivan; Kresse, Kayleigh M.; Whitesides, George McClelland (Royal Society of Chemistry (RSC), 2015)
      This paper reports the development of Metal-amplified Density Assays, or MADAs – a method of conducting quantitative or multiplexed assays, including immunoassays, by using Magnetic Levitation (MagLev) to measure metal-amplified ...

    • Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults 

      Zonneveld, Rens; Martinelli, Roberta; Shapiro, Nathan I; Kuijpers, Taco W; Plötz, Frans B; Carman, Christopher V (BioMed Central, 2014)
      Sepsis is a severe and life-threatening systemic inflammatory response to infection that affects all populations and age groups. The pathophysiology of sepsis is associated with aberrant interaction between leukocytes and ...

    • Tie2 protects the vasculature against thrombus formation in systemic inflammation 

      Higgins, Sarah; De Ceunynck, Karen; Kellum, John; Chen, Xiuying; Gu, Xuesong; Chaudhry, Sharjeel; Schulman, Sol; Libermann, Towia; Lu, Shulin; Shapiro, Nathan; Christiani, David; Flaumenhaft, Robert; Parikh, & (American Society for Clinical Investigation, 2018-03-05)
      Disordered coagulation contributes to death in sepsis and lacks effective treatments. Existing markers of disseminated intravascular coagulation (DIC) reflect its sequelae rather than its causes, delaying diagnosis and ...

    • Utility of Chest Radiography in Emergency Department Patients Presenting with Syncope 

      Wong, Matthew L.; Chiu, David; Shapiro, Nathan I; Grossman, Shamai A (Department of Emergency Medicine, University of California, Irvine School of Medicine, 2016)
      Introduction: Syncope has myriad etiologies, ranging from benign to immediately life threatening. This frequently leads to over testing. Chest radiographs (CXR) are among these commonly performed tests despite their uncertain ...

    • The Yield of Head CT in Syncope: A Pilot Study 

      Bar, J. L.; Mottley, L.; Grossman, Shamai Aaron; Fischer, Christopher M; Lipsitz, Lewis Arnold; Sands, Kenneth Eliot Frederick; Thompson, Sylvia V; Shapiro, Nathan Ivan; Zimetbaum, Peter J.; Thompson, Sally Wright (Springer-Verlag, 2007)
      Although head CT is often routinely performed in emergency department (ED) patients with syncope, few studies have assessed its value. Objectives: To determine the yield of routine head CT in ED patients with syncope and ...