Now showing items 1-5 of 5

    • Analysis of growth factor signaling in genetically diverse breast cancer lines 

      Niepel, Mario; Hafner, Marc; Pace, Emily A; Chung, Mirra; Chai, Diana H; Zhou, Lili; Muhlich, Jeremy L; Schoeberl, Birgit; Sorger, Peter K (BioMed Central, 2014)
      Background: Soluble growth factors present in the microenvironment play a major role in tumor development, invasion, metastasis, and responsiveness to targeted therapies. While the biochemistry of growth factor-dependent ...
    • Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold 

      Roux, Jérémie; Hafner, Marc; Bandara, Samuel; Sims, Joshua J; Hudson, Hannah; Chai, Diana; Sorger, Peter K (BlackWell Publishing Ltd, 2015)
      When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re-exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies ...
    • Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs 

      Hafner, Marc; Niepel, Mario; Chung, Mirra; Sorger, Peter K. (2016)
      Drug sensitivity and resistance are conventionally quantified by IC50 or Emax values, but these metrics are highly sensitive to the number of divisions taking place over the course of a response assay. The dependency of ...
    • LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures 

      Duan, Qiaonan; Flynn, Corey; Niepel, Mario; Hafner, Marc; Muhlich, Jeremy L.; Fernandez, Nicolas F.; Rouillard, Andrew D.; Tan, Christopher M.; Chen, Edward Y.; Golub, Todd R.; Sorger, Peter K.; Subramanian, Aravind; Ma'ayan, Avi (Oxford University Press, 2014)
      For the Library of Integrated Network-based Cellular Signatures (LINCS) project many gene expression signatures using the L1000 technology have been produced. The L1000 technology is a cost-effective method to profile gene ...
    • Mapping behavioral specifications to model parameters in synthetic biology 

      Koeppl, Heinz; Hafner, Marc; Lu, James (BioMed Central, 2013)
      With recent improvements of protocols for the assembly of transcriptional parts, synthetic biological devices can now more reliably be assembled according to a given design. The standardization of parts open up the way for ...