Browsing by Author "Chang, Roger"

Now showing items 1-4 of 4

    • Antibacterial mechanisms identified through structural systems pharmacology 

      Chang, Roger L; Xie, Lei; Bourne, Philip E; Palsson, Bernhard O (BioMed Central, 2013)
      Background: The growing discipline of structural systems pharmacology is applied prospectively in this study to predict pharmacological outcomes of antibacterial compounds in Escherichia coli K12. This work builds upon ...

    • Streptomyces thermoautotrophicus does not fix nitrogen 

      MacKellar, Drew; Lieber, Lucas; Norman, Jeffrey S.; Bolger, Anthony; Tobin, Cory; Murray, James W.; Oksaksin, Mehtap; Chang, Roger L.; Ford, Tyler J.; Nguyen, Peter Q.; Woodward, Jimmy; Permingeat, Hugo R.; Joshi, Neel S.; Silver, Pamela A.; Usadel, Björn; Rutherford, Alfred W.; Friesen, Maren L.; Prell, Jürgen (Nature Publishing Group, 2016)
      Streptomyces thermoautotrophicus UBT1 has been described as a moderately thermophilic chemolithoautotroph with a novel nitrogenase enzyme that is oxygen-insensitive. We have cultured the UBT1 strain, and have isolated two ...

    • Systems biology of the structural proteome 

      Brunk, Elizabeth; Mih, Nathan; Monk, Jonathan; Zhang, Zhen; O’Brien, Edward J.; Bliven, Spencer E.; Chen, Ke; Chang, Roger L.; Bourne, Philip E.; Palsson, Bernhard O. (BioMed Central, 2016)
      Background: The success of genome-scale models (GEMs) can be attributed to the high-quality, bottom-up reconstructions of metabolic, protein synthesis, and transcriptional regulatory networks on an organism-specific basis. ...

    • Transplantability of a circadian clock to a noncircadian organism 

      Chen, Anna H.; Lubkowicz, David; Yeong, Vivian; Chang, Roger L.; Silver, Pamela A. (2015)
      Circadian oscillators are posttranslationally regulated and affect gene expression in autotrophic cyanobacteria. Oscillations are controlled by phosphorylation of the KaiC protein, which is modulated by the KaiA and KaiB ...