Now showing items 1-3 of 3

    • Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target 

      Chen, Ting; Ozel, Duygu; Qiao, Yuan; Harbinski, Fred; Chen, Limo; Denoyelle, Séverine; He, Xiaoying; Zvereva, Nela; Supko, Jeffrey G.; Chorev, Michael; Halperin, Jose A.; Aktas, Bertal H. (2013)
      Translation initiation plays a critical role in cellular homeostasis, proliferation, differentiation and malignant transformation. Consistently, increasing the abundance of the eIF2·GTP·Met-tRNAi translation initiation ...
    • A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme 

      Rosenfeld, Myrna R; Ye, Xiaobu; Supko, Jeffrey G; Desideri, Serena; Grossman, Stuart A; Brem, Steven; Mikkelson, Tom; Wang, Daniel; Chang, Yunyoung C; Hu, Janice; McAfee, Quentin; Fisher, Joy; Troxel, Andrea B; Piao, Shengfu; Heitjan, Daniel F; Tan, Kay-See; Pontiggia, Laura; O’Dwyer, Peter J; Davis, Lisa E; Amaravadi, Ravi K (Landes Bioscience, 2014)
      Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and ...
    • Tumor suppression by small molecule inhibitors of translation initiation 

      Chen, Limo; Aktas, Bertal H.; Wang, Yibo; He, Xiaoying; Sahoo, Rupam; Zhang, Nancy; Denoyelle, Severine; Kabha, Eihab; Yang, Hongwei; Freedman, Revital; Supko, Jeffrey G.; Chorev, Michael; Wagner, Gerhard; Halperin, Jose Alberto (Impact Journals LLC, 2012)
      Translation initiation factors are over-expressed and/or activated in many human cancers and may contribute to their genesis and/or progression. Removal of physiologic restraints on translation initiation causes malignant ...