Now showing items 1-2 of 2

    • High-dimensional genomic data bias correction and data integration using MANCIE 

      Zang, Chongzhi; Wang, Tao; Deng, Ke; Li, Bo; Hu, Sheng'en; Qin, Qian; Xiao, Tengfei; Zhang, Shihua; Meyer, Clifford A.; He, Housheng Hansen; Brown, Myles; Liu, Jun S.; Xie, Yang; Liu, X. Shirley (Nature Publishing Group, 2016)
      High-dimensional genomic data analysis is challenging due to noises and biases in high-throughput experiments. We present a computational method matrix analysis and normalization by concordant information enhancement ...
    • Network analysis of gene essentiality in functional genomics experiments 

      Jiang, Peng; Wang, Hongfang; Li, Wei; Zang, Chongzhi; Li, Bo; Wong, Yinling J.; Meyer, Cliff; Liu, Jun S.; Aster, Jon C.; Liu, X. Shirley (BioMed Central, 2015)
      Many genomic techniques have been developed to study gene essentiality genome-wide, such as CRISPR and shRNA screens. Our analyses of public CRISPR screens suggest protein interaction networks, when integrated with gene ...