Now showing items 1-3 of 3

    • Atypical calcium regulation of the PKD2-L1 polycystin ion channel 

      DeCaen, Paul G; Liu, Xiaowen; Abiria, Sunday; Clapham, David E (eLife Sciences Publications, Ltd, 2016)
      Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior ...
    • Molecular basis of ion permeability in a voltage‐gated sodium channel 

      Naylor, Claire E; Bagnéris, Claire; DeCaen, Paul G; Sula, Altin; Scaglione, Antonella; Clapham, David E; Wallace, BA (John Wiley and Sons Inc., 2016)
      Abstract Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events ...
    • Role of the C-terminal domain in the structure and function of tetrameric sodium channels 

      Bagnéris, Claire; DeCaen, Paul G.; Hall, Benjamin A.; Naylor, Claire E.; Clapham, David E.; Kay, Christopher W. M.; Wallace, B. A. (Nature Pub. Group, 2013)
      Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal ...