Browsing by Author "MacFarlane, Lindsey"

Now showing items 1-3 of 3

    • Atherogenesis in Mice Does Not Require CD40 Ligand from Bone Marrow-Derived Cells 

      Bavendiek, Udo; Zirlik, Andreas; LaClair, Samantha; MacFarlane, Lindsey Adair; Libby, Peter; Schönbeck, Uwe (American Heart Association, 2005)
      Objective. Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown. To test the hypothesis that CD40L expressed ...

    • Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice 

      Sun, Jiusong; Sukhova, Galina K.; Yang, Min; Wolters, Paul J.; MacFarlane, Lindsey Adair; Libby, Peter; Sun, Chongxiu; Zhang, Yadong; Liu, Jianming; Ennis, Terri L.; Knispel, Rebecca; Xiong, Wanfen; Thompson, Robert W.; Baxter, B. Timothy; Shi, Guo-Ping (American Society for Clinical Investigation, 2007)
      Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of ...

    • Metformin Inhibits Proinflammatory Responses and Nuclear Factor-\(\kappa\)B in Human Vascular Wall Cells 

      Isoda, Kikuo; Young, James Leroy; Zirlik, Andreas; MacFarlane, Lindsey Adair; Tsuboi, Naotake; Gerdes, Norbert; Schönbeck, Uwe; Libby, Peter (American Heart Association, 2006)
      Objective. Metformin may benefit the macrovascular complications of diabetes independently of its conventional hypoglycemic effects. Accumulating evidence suggests that inflammatory processes participate in type 2 diabetes ...