Browsing by Author "Jeong, Ha-Won"
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SALL4, a Stem Cell Factor, Affects the Side Population by Regulation of the ATP-Binding Cassette Drug Transport Genes
Jeong, Ha-Won; Cui, Wei; Yang, Yang; Lu, Jiayun; He, Jie; Li, Lingling; Song, David; Guo, Ye; Liu, Bee H.; Chai, Li (Public Library of Science, 2011)Our previous work shows that the stem cell factor SALL4 plays a central role in embryonic and leukemic stem cells. In this study, we report that SALL4 expression was higher in drug resistant primary acute myeloid leukemic ... -
The Salmonella SPI2 Effector SseI Mediates Long-Term Systemic Infection by Modulating Host Cell Migration
McLaughlin, Laura M.; Govoni, Gregory R.; Gerke, Christiane; Gopinath, Smita; Peng, Kaitian; Laidlaw, Grace; Chien, Yueh-Hsiu; Li, Zhigang; Monack, Denise; Jeong, Ha-Won; Brown, Matthew D.; Sacks, David Barry (Public Library of Science, 2009)Host-adapted strains of Salmonella enterica cause systemic infections and have the ability to persist systemically for long periods of time despite the presence of a robust immune response. Chronically infected hosts are ... -
Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
Lu, Jiayun; Kong, Nikki; Carroll, John; Capogrossi, Maurizio; Jeong, Ha-Won; Yang, Yang; Luo, Hongbo; Silberstein, Leslie E.; Chai, Li; Ma, Yupo (Public Library of Science, 2009)Background The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both development and leukemogenesis. It is a unique gene that is involved in self-renewal in ESC and leukemic stem cell (LSC).Methodology/Principal ... -
Targeting Transcription Factor SALL4 in Acute Myeloid Leukemia by Interrupting Its Interaction with an Epigenetic Complex
Gao, Chong; Dimitrov, Todor; Yong, Kol Jia; Tatetsu, Hiro; Jeong, Ha-Won; Luo, Hongbo; Bradner, James Elliott; Tenen, Daniel Geoffrey; Chai, Li (American Society of Hematology, 2013)An exciting recent approach to targeting transcription factors in cancer is to block formation of oncogenic complexes. We investigated whether interfering with the interaction of the transcription factor SALL4, which is ...