Browsing by Author "Haigis, Kevin"
Now showing items 1-4 of 4
-
Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening
Wood, Levi B.; Winslow, Ashley R.; Proctor, Elizabeth A.; McGuone, Declan; Mordes, Daniel A.; Frosch, Matthew P.; Hyman, Bradley T.; Lauffenburger, Douglas A.; Haigis, Kevin M. (Nature Publishing Group, 2015)Alzheimer’s disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since ... -
Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation
Cho, Hansang; Hashimoto, Tadafumi; Wong, Elisabeth; Hori, Yukiko; Wood, Levi Benjamin; Zhao, Lingzhi; Haigis, Kevin M; Hyman, Bradley Theodore; Irimia, Daniel (Nature Publishing Group, 2013)Progressive microglial accumulation at amyloid-β (Aβ) plaques is a well-established signature of the pathology of Alzheimer's disease, but how and why microglia accumulate in the vicinity of Aβ plaques is unknown. To ... -
Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium
Lau, Ken; Cortez-Retamozo, Virna; Philips, Sarah R.; Pittet, Mikael J.; Lauffenburger, Douglas A.; Haigis, Kevin M (Public Library of Science, 2012)An intercellular communication network that controls intestinal homeostasis in animals treated acutely with the pro-inflammatory cytokine TNF-α is uncovered by multi-scale systems analysis. -
p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis
Kirsch, David G.; Santiago, Philip M.; Di Tomaso, Emmanuelle; Sullivan, Julie M.; Hou, Wu-Shiun; Dayton, Talya; Jeffords, Laura B.; Sodha, Pooja; Mercer, Kim; Cohen, Rhianna; Takeushi, Osamu; Takeuchi, Osamu; Korsmeyer, Stanley J.; Bronson, Roderick; Kim, Carla; Haigis, Kevin; Jain, Rakesh; Jacks, Tyler (American Association for the Advancement of Science (AAAS), 2009-12-17)Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells mediating the GI syndrome are derived from the epithelium or ...