Browsing by Author "Madi, Asaf"

Now showing items 1-3 of 3

    • IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation 

      Mayo, Lior; Cunha, Andre Pires Da; Madi, Asaf; Beynon, Vanessa; Yang, Zhiping; Alvarez, Jorge I.; Prat, Alexandre; Sobel, Raymond A.; Kobzik, Lester; Lassmann, Hans; Quintana, Francisco J.; Weiner, Howard L. (Oxford University Press, 2016)
      See Winger and Zamvil (doi:10.1093/brain/aww121) for a scientific commentary on this article. The innate immune system plays a central role in the chronic central nervous system inflammation that drives neurological ...

    • Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation 

      Schnell, Alexandra; Huang, Linglin; Regan, Brianna; Vonficht, Dominik; Bollhagen, Alina; Wang, Mona; Hou, Yu; Bod, Lloyd; Chihara, Norio; Madi, Asaf; Anderson, Ana; Kuchroo, Vijay (Springer Science and Business Media LLC, 2023-10-12)
      Co-inhibitory and checkpoint molecules suppress T-cell function in the tumor microenvironment, thereby rendering T cells dysfunctional. While immune checkpoint blockade (ICB) has emerged as a successful treatment option ...

    • TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection 

      Jayaraman, Pushpa; Jacques, Miye K.; Zhu, Chen; Steblenko, Katherine M.; Stowell, Britni L.; Madi, Asaf; Anderson, Ana C.; Kuchroo, Vijay K.; Behar, Samuel M. (Public Library of Science, 2016)
      While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ...