Browsing by Author "Fuller, Patrick"
Now showing items 1-5 of 5
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Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions
Vetrivelan, Ramalingam; Saper, Clifford B; Fuller, Patrick M (Dove Medical Press, 2014)Armodafinil is the pharmacologically active R-enantiomer of modafinil, a widely prescribed wake-promoting agent used to treat several sleep-related disorders including excessive daytime sleepiness associated with narcolepsy, ... -
Basal forebrain control of wakefulness and cortical rhythms
Anaclet, Christelle; Pedersen, Nigel P.; Ferrari, Loris L.; Venner, Anne; Bass, Caroline E.; Arrigoni, Elda; Fuller, Patrick M. (Nature Pub. Group, 2015)Wakefulness, along with fast cortical rhythms and associated cognition, depend on the basal forebrain (BF). BF cholinergic cell loss in dementia and the sedative effect of anti-cholinergic drugs have long implicated these ... -
GABAergic parafacial zone is a medullary slow–wave–sleep promoting center
Anaclet, Christelle; Ferrari, Loris; Arrigoni, Elda; Bass, Caroline E.; Saper, Clifford B.; Lu, Jun; Fuller, Patrick M. (2014)Work in animals and humans suggest the existence of a slow–wave sleep (SWS) promoting/EEG synchronizing center in the mammalian lower brainstem. While sleep–active GABAergic neurons in the medullary parafacial zone (PZ) ... -
How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake
Fuller, Patrick M; Yamanaka, Akihiro; Lazarus, Michael (Taylor & Francis, 2015)The advent of genetically engineered systems, including transgenic animals and recombinant viral vectors, has facilitated a more detailed understanding of the molecular and cellular substrates regulating brain function. ... -
Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals
Gompf, Heinrich S.; Budygin, Evgeny A.; Fuller, Patrick M.; Bass, Caroline E. (Frontiers Media S.A., 2015)Techniques to genetically manipulate the activity of defined neuronal subpopulations have been useful in elucidating function, however applicability to translational research beyond transgenic mice is limited. Subtype ...