Now showing items 1-6 of 6

    • CD39 and Control of Cellular Immune Responses 

      Dwyer, Karen M.; Deaglio, Silvia; Gao, Wenda; Friedman, David J.; Strom, Terry Barton; Robson, Simon Christopher (Springer Verlag, 2007)
      CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic ...
    • Copy Number Variation at the APOL1 Locus 

      Ruchi, Rupam; Genovese, Giulio; Lee, Jessica; Charoonratana, Victoria T.; Bernhardy, Andrea J.; Alper, Seth L.; Kopp, Jeffrey B.; Thadhani, Ravi; Friedman, David J.; Pollak, Martin R. (Public Library of Science, 2015)
      Two coding variants in the APOL1 gene (G1 and G2) explain most of the high rate of kidney disease in African Americans. APOL1-associated kidney disease risk inheritance follows an autosomal recessive pattern: The relative ...
    • Functional ENTPD1 Polymorphisms in African Americans With Diabetes and End-Stage Renal Disease 

      Friedman, David J.; Talbert, Matthew E.; Bowden, Donald W.; Freedman, Barry I.; Mukanya, Yves; Enjyoji, Keiichi; Robson, Simon Christopher (American Diabetes Association, 2008)
      Objective: The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation in ENTPD1 influences predisposition to diabetes ...
    • Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies 

      Zaitlen, Noah; Lindström, Sara; Pasaniuc, Bogdan; Cornelis, Marilyn; Genovese, Giulio; Pollack, Samuela; Barton, Anne; Bickeböller, Heike; Bowden, Donald W.; Eyre, Steve; Freedman, Barry I.; Friedman, David J.; Field, John K.; Groop, Leif; Haugen, Aage; Heinrich, Joachim; Henderson, Brian E.; Hicks, Pamela J.; Hocking, Lynne J.; Kolonel, Laurence N.; Landi, Maria Teresa; Langefeld, Carl D.; Le Marchand, Loic; Meister, Michael; Morgan, Ann W.; Raji, Olaide Y.; Risch, Angela; Rosenberger, Albert; Scherf, David; Steer, Sophia; Walshaw, Martin; Waters, Kevin M.; Wilson, Anthony G.; Wordsworth, Paul; Zienolddiny, Shanbeh; Tchetgen, Eric Tchetgen; Haiman, Christopher; Hunter, David J.; Plenge, Robert M.; Worthington, Jane; Christiani, David C.; Schaumberg, Debra Ann; Chasman, Daniel Ian; Altshuler, David Matthew; Voight, Benjamin; Kraft, Peter Elias; Patterson, Nick; Price, Alkes (Public Library of Science, 2012)
      Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, ...
    • Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1 

      Nichols, Brendan; Jog, Prachi; Lee, Jessica; Blackler, Daniel; Wilmot, Michael; D’Agati, Vivette; Markowitz, Glen; Kopp, Jeffrey; Alper, Seth L.; Pollak, Martin R.; Friedman, David J. (2014)
      Apolipoprotein L1 (APOL1) risk variants greatly elevate the risk of kidney disease in African Americans. Here we report a cohort of patients who developed collapsing focal segmental glomerulosclerosis while receiving ...
    • Staphylococcus aureus Redirects Central Metabolism to Increase Iron Availability 

      Friedman, David J.; Stauff, Devin L; Pishchany, Gleb; Whitwell, Corbin W; Torres, Victor J; Skaar, Eric P (Public Library of Science, 2006)
      Staphylococcus aureus pathogenesis is significantly influenced by the iron status of the host. However, the regulatory impact of host iron sources on S. aureus gene expression remains unknown. In this study, we combine ...