Browsing by Author "Wang, Xiaodan"

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Enhanced Nigrostriatal Neuron-specific, Long-term Expression by Using Neural-specific Promoters in Combination with Targeted Gene Transfer by Modified Helper Virus-free HSV-1 Vector Particles

Cao, Haiyan; Zhang, Guo-Rong; Wang, Xiaodan; Kong, Lingxin; Geller, Alfred I. (BioMed Central, 2008)

Background: Direct gene transfer into neurons has potential for developing gene therapy treatments for specific neurological conditions, and for elucidating neuronal physiology. Due to the complex cellular composition of ...
Improved Long-term Expression from Helper Virus-free HSV-1 Vectors Packaged Using Combinations of Mutated HSV-1 Proteins that Include the UL13 Protein Kinase and Specific Components of the VP16 Transcriptional Complex

Liu, Meng; Wang, Xiaodan; Geller, Alfred I. (BioMed Central, 2009)

Background: Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only ...
Pax3 Stimulates p53 Ubiquitination and Degradation Independent of Transcription

Wang, Xiaodan; Morgan, Sarah C.; Loeken, Mary Rose (Public Library of Science, 2011)

Background: Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac ...