Now showing items 1-2 of 2

    • Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway 

      Chan, PuiYee; Han, Xiao; Zheng, Baohui; DeRan, Michael; Yu, Jianzhong; Jarugumilli, Gopala K.; Deng, Hua; Pan, Duojia; Luo, Xuelian; Wu, Xu (2016)
      TEA domain (TEAD) transcription factors bind to the co-activator YAP/TAZ, and regulate the transcriptional output of Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation ...
    • ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity 

      Chen, Baoen; Zheng, Baohui; DeRan, Micael; Jarugumilli, Gopala K.; Fu, Jianjun; Brooks, Yang S.; Wu, Xu (2016)
      Scribble (SCRIB) is a tumor suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. Paradoxically, SCRIB is frequently amplified in human cancers, however, fails to localize ...