Now showing items 1-7 of 7

    • Asbestos Burden Predicts Survival in Pleural Mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Roelofs, Cora R.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Marsit, Carmen J.; Nelson, Heather H.; Kelsey, Karl T. (National Institute of Environmental Health Sciences, 2008)
      Background: Malignant pleural mesothelioma (MPM) is a rapidly fatal asbestos-associated malignancy with a median survival time of < 1 year following diagnosis. Treatment strategy is determined in part using known ...
    • Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Marsit, Carmen J.; Houseman, Eugene Andres; Lopez-Fagundo, Cristina Y.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Nelson, Heather H.; Kelsey, Karl T. (Oxford University Press, 2008)
      Malignant pleural mesothelioma (MPM) is a rapidly fatal tumor with increasing incidence worldwide responsible for many thousands of deaths annually. Although there is a clear link between exposure to asbestos and mesothelioma, ...
    • Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines 

      Bartoli, Carlo R.; Wellenius, Gregory A.; Coull, Brent Andrew; Akiyama, Ichiro; Diaz, Edgar; Lawrence, Joy E.; Okabe, Kazunori; Verrier, Richard Leonard; Godleski, John Joseph (National Institute of Environmental Health Sciences, 2008)
      Background: Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia. Objectives: We conducted this study to investigate the effects ...
    • In vivo evaluation of chemical biopersistence of nonfibrous inorganic particles. 

      Brain, Joseph David; Godleski, John Joseph; Kreyling, W (1994)
      The lung's response to deposited particles may depend upon the physical-chemical properties of the particles, the amount initially deposited, and the persistence of the particles. Clearance involves mucociliary transport ...
    • Innate Immunity Immunomodulators in Post-Influenza Bacterial Pneumonia 

      Wu, Muzo (2015-05-01)
      Post-influenza bacterial pneumonia is a major cause of morbidity and mortality worldwide. One mechanism for enhanced susceptibility to bacterial infection after influenza is down-regulation of a major phagocytic receptor ...
    • Mechanisms of Inhaled Fine Particulate Air Pollution–induced Arterial Blood Pressure Changes 

      Bartoli, Carlo R.; Wellenius, Gregory A.; Diaz, Edgar; Lawrence, Joy E.; Coull, Brent Andrew; Akiyama, Ichiro; Lee, Lani M.; Okabe, Kazunori; Verrier, Richard Leonard; Godleski, John Joseph (National Institute of Environmental Health Sciences, 2008)
      Background: Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent. Objectives: We investigated the effect of ambient particles ...
    • Particulate Matter (PM) Research Centers (1999–2005) and the Role of Interdisciplinary Center-based Research 

      Fanning, Elinor W.; Froines, John R.; Utell, Mark J.; Lippmann, Morton; Oberdörster, Gunter; Frampton, Mark; Larson, Tim V.; Godleski, John Joseph (National Institute of Environmental Health Sciences, 2008)
      Objective: The U.S. Environmental Protection Agency funded five academic centers in 1999 to address the uncertainties in exposure, toxicity, and health effects of airborne particulate matter (PM) identified in the “Research ...