Now showing items 1-5 of 5

    • Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma 

      Jham, Bruno C.; Ma, Tao; Hu, Jiadi; Chaisuparat, Risa; Friedman, Eitan R.; Pandolfi, Pier Paolo; Schneider, Abraham; Sodhi, Akrit; Montaner, Silvia (Public Library of Science, 2011)
      Background: Kaposi’s sarcoma (KS) is a vascular neoplasm characterized by the dysregulated expression of angiogenic and inflammatory cytokines. The driving force of the KS lesion, the KSHV-infected spindle cell, secretes ...
    • CIP2A Promotes Proliferation of Spermatogonial Progenitor Cells and Spermatogenesis in Mice 

      Ventelä, Sami; Côme, Christophe; Mäkelä, Juho-Antti; Hobbs, Robin M.; Mannermaa, Leni; Kallajoki, Markku; Chan, Edward K.; Pandolfi, Pier Paolo; Toppari, Jorma; Westermarck, Jukka (Public Library of Science, 2012)
      Protein phosphatase 2A (PP2A) is a critical regulator of protein serine/threonine phosphorylation. However, the physiological and developmental roles of different PP2A complexes are very poorly understood. Here, we show ...
    • Pml Represses Tumour Progression Through Inhibition of mTOR 

      Bernardi, Rosa; Papa, Antonella; Egia, Ainara; Coltella, Nadia; Teruya-Feldstein, Julie; Signoretti, Sabina; Pandolfi, Pier Paolo (Wiley-VCH Verlag Berlin, 2011)
      The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes \(mTOR-HIF1\alpha -VEGF\) signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in ...
    • The Proto-Oncogene LRF Is Under Post-Transcriptional Control of MiR-20a: Implications for Senescence 

      Poliseno, Laura; Pitto, Letizia; Simili, Marcella; Mariani, Laura; Riccardi, Luisa; Ciucci, Alessia; Rizzo, Milena; Evangelista, Monica; Mercatanti, Alberto; Pandolfi, Pier Paolo; Rainaldi, Giuseppe (Public Library of Science, 2008)
      MicroRNAs (miRNAs) are short 20–22 nucleotide RNA molecules that act as negative regulators of gene expression via translational repression: they have been shown to play a role in development, proliferation, stress response, ...
    • Translation-Dependent Mechanisms Lead to PML Upregulation and Mediate Oncogenic K-RAS-Induced Cellular Senescence 

      Scaglioni, Pier Paolo; Rabellino, Andrea; Yung, Thomas M.; Bernardi, Rosa; Choi, Sooyeon; Konstantinidou, Georgia; Nardella, Caterina; Cheng, Ke; Pandolfi, Pier Paolo (Wiley, 2012)
      Expression of oncogenic K-RAS in primary cells elicits oncogene-induced cellular senescence (OIS), a form of growth arrest that potently opposes tumourigenesis. This effect has been largely attributed to transcriptional ...