Now showing items 1-20 of 26

    • Automated white matter fiber tract identification in patients with brain tumors 

      O’Donnell, Lauren J.; Suter, Yannick; Rigolo, Laura; Kahali, Pegah; Zhang, Fan; Norton, Isaiah; Albi, Angela; Olubiyi, Olutayo; Meola, Antonio; Essayed, Walid I.; Unadkat, Prashin; Ciris, Pelin Aksit; Wells, William M.; Rathi, Yogesh; Westin, Carl-Fredrik; Golby, Alexandra J. (Elsevier, 2016)
      We propose a method for the automated identification of key white matter fiber tracts for neurosurgical planning, and we apply the method in a retrospective study of 18 consecutive neurosurgical patients with brain tumors. ...
    • Biomarkers for Identifying First-Episode Schizophrenia Patients Using Diffusion Weighted Imaging 

      Rathi, Yogesh; Malcolm, James; Michailovich, Oleg; Goldstein, Jill M.; Seidman, Larry Joel; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Springer Science + Business Media, 2010)
      Recent advances in diffusion weighted MR imaging (dMRI) has made it a tool of choice for investigating white matter abnormalities of the brain and central nervous system. In this work, we design a system that detects ...
    • Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia 

      Asami, Takeshi; Hyuk Lee, Sang; Bouix, Sylvain; Rathi, Yogesh; Whitford, Thomas; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2014)
      Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not ...
    • Directional functions for orientation distribution estimation 

      Rathi, Yogesh; Michailovich, Oleg; Shenton, Martha Elizabeth; Bouix, Sylvain (Elsevier BV, 2009)
      Computing the Orientation Distribution Function (ODF) from High Angular Resolution Diffusion Imaging (HARDI) signals makes it possible to determine the orientation of fiber bundles of the brain. The HARDI signals are samples ...
    • Estimation of Bounded and Unbounded Trajectories in Diffusion MRI 

      Ning, Lipeng; Westin, Carl-Fredrik; Rathi, Yogesh (Frontiers Media S.A., 2016)
      Disentangling the tissue microstructural information from the diffusion magnetic resonance imaging (dMRI) measurements is quite important for extracting brain tissue specific measures. The autocorrelation function of ...
    • A filtered approach to neural tractography using the Watson directional function 

      Malcolm, James G.; Michailovich, Oleg; Bouix, Sylvain; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Rathi, Yogesh (Elsevier BV, 2010)
      We propose a technique to simultaneously estimate the local fiber orientations and perform multifiber tractography. Existing techniques estimate the local fiber orientation at each voxel independently so there is no running ...
    • Filtered Multitensor Tractography 

      Malcolm, James G; Shenton, Martha Elizabeth; Rathi, Yogesh (Institute of Electrical & Electronics Engineers (IEEE), 2010)
      We describe a technique that uses tractography to drive the local fiber model estimation. Existing techniques use independent estimation at each voxel so there is no running knowledge of confidence in the estimated model ...
    • A Geometry-Based Particle Filtering Approach to White Matter Tractography 

      Savadjiev, Peter; Rathi, Yogesh; Malcolm, James G.; Shenton, Martha Elizabeth; Westin, Carl-Fredrik (Springer Science + Business Media, 2010)
      We introduce a fibre tractography framework based on a particle filter which estimates a local geometrical model of the underlying white matter tract, formulated as a `streamline flow' using generalized helicoids. The ...
    • Gray matter alterations in early aging: A diffusion magnetic resonance imaging study 

      Rathi, Yogesh; Pasternak, Ofer; Savadjiev, Peter; Michailovich, O.; Bouix, Sylvain; Kubicki, Marek R.; Westin, Carl-Fredrik; Makris, Nikolaos; Shenton, Martha Elizabeth (Wiley-Blackwell, 2013)
      Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior ...
    • Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography 

      Makris, Nikolaos; Preti, M. G.; Wassermann, D.; Rathi, Yogesh; Papadimitriou, G. M.; Yergatian, C.; Dickerson, Bradford Clark; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2013)
      The middle longitudinal fascicle (MdLF) is a major fiber connection running principally between the superior temporal gyrus and the parietal lobe, neocortical regions of great biological and clinical interest. Although one ...
    • Increased Gray Matter Diffusion Anisotropy in Patients with Persistent Post-Concussive Symptoms following Mild Traumatic Brain Injury 

      Bouix, Sylvain; Pasternak, Ofer; Rathi, Yogesh; Pelavin, Paula E.; Zafonte, Ross; Shenton, Martha E. (Public Library of Science, 2013)
      A significant percentage of individuals diagnosed with mild traumatic brain injury (mTBI) experience persistent post-concussive symptoms (PPCS). Little is known about the pathology of these symptoms and there is often no ...
    • Joint Multi-Fiber NODDI Parameter Estimation and Tractography Using the Unscented Information Filter 

      Reddy, Chinthala P.; Rathi, Yogesh (Frontiers Media S.A., 2016)
      Tracing white matter fiber bundles is an integral part of analyzing brain connectivity. An accurate estimate of the underlying tissue parameters is also paramount in several neuroscience applications. In this work, we ...
    • Label Space: A Coupled Multi-shape Representation 

      Malcolm, James; Rathi, Yogesh; Shenton, Martha Elizabeth; Tannenbaum, Allen (Springer Science + Business Media, 2008)
      Richly labeled images representing several sub-structures of an organ occur quite frequently in medical images. For example, a typical brain image can be labeled into grey matter, white matter or cerebrospinal fluid, each ...
    • Maximum Entropy Estimation of Glutamate and Glutamine in MR Spectroscopic Imaging 

      Rathi, Yogesh; Ning, Lipeng; Michailovich, Oleg; Liao, Huijun; Gagoski, Borjan; Grant, P. Ellen; Shenton, Martha Elizabeth; Stern, Robert Stuart; Westin, Carl-Fredrik; Lin, Alexander Peter (Springer Science + Business Media, 2014)
      Magnetic resonance spectroscopic imaging (MRSI) is often used to estimate the concentration of several brain metabolites. Abnormalities in these concentrations can indicate specific pathology, which can be quite useful in ...
    • Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy 

      Yang, Jimmy Chen; Papadimitriou, George; Eckbo, Ryan; Yeterian, Edward H.; Liang, Lichen; Dougherty, Darin Dean; Bouix, Sylvain; Rathi, Yogesh; Shenton, Martha Elizabeth; Kubicki, Marek R.; Eskandar, Emad; Makris, Nikos (Springer Science + Business Media, 2014)
      Subcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance the orbitofrontal cortex (OFC) in ...
    • Neural Tractography Using an Unscented Kalman Filter 

      Malcolm, James G.; Shenton, Martha Elizabeth; Rathi, Yogesh (Springer Science + Business Media, 2009)
      We describe a technique to simultaneously estimate a local neural fiber model and trace out its path. Existing techniques estimate the local fiber orientation at each voxel independently so there is no running knowledge ...
    • On Describing Human White Matter Anatomy: The White Matter Query Language 

      Wassermann, Demian; Makris, Nikos; Rathi, Yogesh; Shenton, Martha Elizabeth; Kikinis, Ron; Kubicki, Marek R.; Westin, Carl-Fredrik (Springer Science + Business Media, 2013)
      The main contribution of this work is the careful syntactical definition of major white matter tracts in the human brain based on a neuroanatomist’s expert knowledge. We present a technique to formally describe white matter ...
    • Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography 

      Chen, Zhenrui; Tie, Yanmei; Olubiyi, Olutayo; Rigolo, Laura; Mehrtash, Alireza; Norton, Isaiah; Pasternak, Ofer; Rathi, Yogesh; Golby, Alexandra J.; O'Donnell, Lauren J. (Elsevier, 2015)
      Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema ...
    • A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury 

      Shenton, Martha Elizabeth; Hamoda, Hesham; Schneiderman, J. S.; Bouix, Sylvain; Pasternak, Ofer; Rathi, Yogesh; Vu, M.-A.; Purohit, Maulik Prafull; Helmer, Karl G.; Koerte, Inga Katharina; Lin, Alexander Peter; Westin, Carl-Fredrik; Kikinis, Ron; Kubicki, Marek R.; Stern, R. A.; Zafonte, Ross Dennis (Springer Science + Business Media, 2012)
      Mild traumatic brain injury (mTBI), also referred to as concussion, remains a controversial diagnosis because the brain often appears quite normal on conventional computed tomography (CT) and magnetic resonance imaging ...
    • Sparse Multi-Shell Diffusion Imaging 

      Rathi, Yogesh; Michailovich, O.; Setsompop, Kawin; Bouix, Sylvain; Shenton, Martha Elizabeth; Westin, Carl-Fredrik (Springer Science + Business Media, 2011)
      Diffusion magnetic resonance imaging (dMRI) is an important tool that allows non-invasive investigation of neural architecture of the brain. The data obtained from these in-vivo scans provides important information about ...