Browsing by Author "Dietrich, Jorg"
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Engraftment of enteric neural progenitor cells into the injured adult brain
Belkind-Gerson, Jaime; Hotta, Ryo; Whalen, Michael; Nayyar, Naema; Nagy, Nandor; Cheng, Lily; Zuckerman, Aaron; Goldstein, Allan M.; Dietrich, Jorg (BioMed Central, 2016)Background: A major area of unmet need is the development of strategies to restore neuronal network systems and to recover brain function in patients with neurological disease. The use of cell-based therapies remains an ... -
Improved Tumor Oxygenation and Survival in Glioblastoma Patients Who Show Increased Blood Perfusion After Cediranib and Chemoradiation
Batchelor, Tracy; Gerstner, Elizabeth; Emblem, Kyrre E.; Duda, Dan; Kalpathy-Cramer, Jayashree; Snuderl, Matija; Ancukiewicz, Marek; Polaskova, Pavlina; Pinho, Marco C.; Jennings, Dominique; Plotkin, Scott; Chi, Andrew S.; Eichler, April; Dietrich, Jorg; Hochberg, Fred H.; Lu-Emerson, Christine; Iafrate, Anthony; Ivy, S. Percy; Rosen, Bruce; Loeffler, Jay; Wen, Patrick; Sorenson, A. Greg; Jain, Rakesh (National Academy of Sciences, 2013-11-19)Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and ... -
Systemic 5-fluorouracil Treatment Causes a Syndrome of Delayed Myelin Destruction in the Central Nervous System
Han, Ruolan; Yang, Yin Miranda; Dietrich, Jorg; Luebke, Anne; Mayer-Pröschel, Margot; Noble, Mark (BioMed Central, 2008)Background: Cancer treatment with a variety of chemotherapeutic agents often is associated with delayed adverse neurological consequences. Despite their clinical importance, almost nothing is known about the basis for such ... -
Systemic chemotherapy decreases brain glucose metabolism
Horky, Laura L; Gerbaudo, Victor H; Zaitsev, Alexander; Plesniak, Wen; Hainer, Jon; Govindarajulu, Usha; Kikinis, Ron; Dietrich, Jörg (BlackWell Publishing Ltd, 2014)Objective: Cancer patients may experience neurologic adverse effects, such as alterations in neurocognitive function, as a consequence of chemotherapy. The mechanisms underlying such neurotoxic syndromes remain poorly ...