Browsing by Author "Gu, Chenghua"
Now showing items 1-7 of 7
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Characterization of the In Vivo Function of Neuropilin1 during Development
Gelfand, Maria (2013-02-20)Neuropilin1 (Npn1) is a transmembrane receptor that is critical for development of both the nervous and vascular systems. It is a ligand for both the chemorepulsive Semaphorin3s and for vascular endothelial growth factor ... -
Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition
Kwon, Hyung-Bae; Kozorovitskiy, Yevgenia; Oh, Won-Jong; Peixoto, Rui T.; Akhtar, Nazia; Saulnier, Jessica L.; Gu, Chenghua; Sabatini, Bernardo L. (2012)Members of the neuroligin (NL) family of cell-adhesion proteins are found at excitatory and inhibitory synapses and are mutated in some familial forms of autism spectrum disorders. Although they display synaptogenic ... -
An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E–PlexinD1 signaling
Tata, Aleksandra; Stoppel, David C.; Hong, Shangyu; Ben-Zvi, Ayal; Xie, Tiao; Gu, Chenghua (The Rockefeller University Press, 2014)Extracellular signals have to be precisely interpreted intracellularly and translated into diverse cellular behaviors often mediated by cytoskeletal changes. Semaphorins are one of the largest families of guidance cues and ... -
Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis
Tritsch, Nicolas X; Oh, Won-Jong; Gu, Chenghua; Sabatini, Bernardo L (eLife Sciences Publications, Ltd, 2014)Synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. Recent evidence indicates that nigrostriatal dopamine neurons inhibit ... -
Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding
Gelfand, Maria V; Hagan, Nellwyn; Tata, Aleksandra; Oh, Won-Jong; Lacoste, Baptiste; Kang, Kyu-Tae; Kopycinska, Justyna; Bischoff, Joyce; Wang, Jia-Huai; Gu, Chenghua (eLife Sciences Publications, Ltd, 2014)During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and ... -
Structure and mechanism of blood–brain-barrier lipid transporter MFSD2A
Wood, Chase A. P.; Zhang, Jinru; Aydin, Deniz; Xu, Yan; Andreone, Benjamin J.; Langen, Urs H.; Dror, Ron O.; Gu, Chenghua; Feng, Liang (Springer Science and Business Media LLC, 2021-08-04) -
Temporal modulation of collective cell behavior controls vascular network topology
Kur, Esther; Kim, Jiha; Tata, Aleksandra; Comin, Cesar H; Harrington, Kyle I; Costa, Luciano da F; Bentley, Katie; Gu, Chenghua (eLife Sciences Publications, Ltd, 2016)Vascular network density determines the amount of oxygen and nutrients delivered to host tissues, but how the vast diversity of densities is generated is unknown. Reiterations of endothelial-tip-cell selection, sprout ...