Now showing items 1-2 of 2

    • Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning 

      Saez, Borja; Ferraro, F.; Yusuf, Rushdia Zareen; Cook, Colleen M.; Yu, Vionnie Wing Chi; Pardo-Saganta, A.; Sykes, Stephen M.; Palchaudhuri, Rahul; Schajnovitz, Amir; Lotinun, S; Lymperi, Stefania; Mendez-Ferrer, Simon; del Toro, Raquel; Day, Robyn Rouviere; Vasic, Radovan; Acharya, Sanket Shyamkant; Baron, Roland; Lin, Charles P.; Yamaguchi, Yu; Wagers, Amy Jo; Scadden, David Thomas (American Society of Hematology, 2014)
      The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM) stromal cells, a known population of skeletal stem/progenitor cells, ...
    • Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin 

      Palchaudhuri, Rahul; Saez, Borja; Hoggatt, Jonathan George; Schajnovitz, Amir; Sykes, David Brian; Tate, Tiffany A; Czechowicz, Agnieszka; Kfoury, Youmna Sami; Ruchika, FNU; Rossi, Derrick J; Verdine, Gregory L.; Mansour, Michael Karim; Scadden, David Thomas (Springer Nature, 2016)
      Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital immunodeficiencies, and other conditions, possibly including AIDS. Autologous HSCT using genetically ...