Browsing by Author "Rollins, Barrett"

Now showing items 1-5 of 5

    • Aspergillus Antigen Induces Robust Th2 Cytokine Production, Inflammation, Airway Hyperreactivity and Fibrosis in the Absence of MCP-1 or CCR2 

      Koth, Laura L; Rodriguez, Madeleine W; Bernstein, Xin Liu; Chan, Salina; Huang, Xiaozhu; Charo, Israel F; Rollins, Barrett Jon; Erle, David J (BioMed Central, 2004)
      Background: Asthma is characterized by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and its receptor, ...

    • BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate 

      Bates, Sara V.; Lakshmanan, Ashwini; Green, Adam L.; Terry, Jefferson; Badalian-Very, Gayane; Rollins, Barrett J.; Fleck, Patricia; Aslam, Muhammad; Degar, Barbara A. (Thieme Medical Publishers, 2013)
      Hemorrhagic pustules with a “blueberry muffin” appearance accompanied by respiratory failure in a neonate present a challenging differential diagnosis that includes infections and neoplasms. We present a case of multiorgan, ...

    • CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice 

      Chen, Xuguang; Wang, Yunyue; Nelson, David; Tian, Sara; Mulvey, Erin; Patel, Bhumi; Conti, Ilaria; Jaen, Juan; Rollins, Barrett J. (Public Library of Science, 2016)
      Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report ...

    • Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma 

      Liu, Yang; Quang, Phong; Braggio, Esteban; Ngo, Hai; Badalian-Very, Gayane; Flores, Ludmila; Zhang, Yong; Sacco, Antonio; Maiso, Patricia; Azab, Abdel Kareem; Azab, Feda; Carrasco, Ruben; Rollins, Barrett J.; Roccaro, Aldo M.; Ghobrial, Irene M. (Public Library of Science, 2013)
      Glucocorticoid-induced TNF receptor (GITR) plays a crucial role in modulating immune response and inflammation, however the role of GITR in human cancers is poorly understood. In this study, we demonstrated that GITR is ...

    • Whole-exome sequencing and clinical interpretation of FFPE tumor samples to guide precision cancer medicine 

      Allen, Eliezer M. Van; Wagle, Nikhil; Stojanov, Petar; Perrin, Danielle L.; Cibulskis, Kristian; Marlow, Sara; Jane-Valbuena, Judit; Friedrich, Dennis C.; Kryukov, Gregory; Carter, Scott L.; McKenna, Aaron; Sivachenko, Andrey; Rosenberg, Mara; Kiezun, Adam; Voet, Douglas; Lawrence, Michael; Lichtenstein, Lee T.; Gentry, Jeff G.; Huang, Franklin W.; Fostel, Jennifer; Farlow, Deborah; Barbie, David; Gandhi, Leena; Lander, Eric S.; Gray, Stacy W.; Joffe, Steven; Janne, Pasi; Garber, Judy; MacConaill, Laura; Lindeman, Neal; Rollins, Barrett; Kantoff, Philip; Fisher, Sheila A.; Gabriel, Stacey; Getz, Gad; Garraway, Levi A. (2013)
      Translating whole exome sequencing (WES) for prospective clinical use may impact the care of cancer patients; however, multiple innovations are necessary for clinical implementation. These include: (1) rapid and robust WES ...