Now showing items 1-10 of 10

    • Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer 

      Tang, Liangdan; Yang, Junzheng; Ng, Shu-Kay; Rodriguez, Noah; Choi, Pui-Wah; Vitonis, Allison; Wang, Kui; McLachlan, Geoffrey J.; Caiazzo, Robert J.; Liu, Brian C.-S.; Welch, William Robert; Cramer, Daniel William; Berkowitz, Ross Stuart; Ng, Shu-Wing (Elsevier BV, 2010)
      Mucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco ...
    • Correlates of the preoperative level of CA125 at presentation of ovarian cancer 

      Cramer, Daniel William; Vitonis, Allison F.; Welch, William Robert; Terry, Kathryn Lynne; Goodman, Annekathryn; Rueda, Bo Ruben; Berkowitz, Ross Stuart (Elsevier BV, 2010)
      Objective CA125 at presentation of ovarian cancer carries important prognostic significance; but, other than tumor characteristics, little is known about factors that influence CA125 levels. We examined the effect of ...
    • Current Chemotherapeutic Management of Patients with Gestational Trophoblastic Neoplasia 

      May, Taymaa; Goldstein, Donald Peter; Berkowitz, Ross Stuart (Hindawi Publishing Corporation, 2011)
      Gestational trophoblastic neoplasia (GTN) describes a heterogeneous group of interrelated lesions that arise from abnormal proliferation of placental trophoblasts. GTN lesions are histologically distinct, malignant lesions ...
    • Differential hRad17 Expression by Histologic Subtype of Ovarian Cancer 

      Young, Jennifer L; Koon, E Colin; Kwong, Joseph; Welch, William Robert; Muto, Michael George; Berkowitz, Ross Stuart; Mok, Samuel C (BioMed Central, 2011)
      Background: In the search for unique ovarian cancer biomarkers, ovarian specific cDNA microarray analysis identified hRad17, a cell cycle checkpoint protein, as over-expressed in ovarian cancer. The aim of this study was ...
    • Direct Identification of an HPV-16 Tumor Antigen from Cervical Cancer Biopsy Specimens 

      Keskin, Derin Benerci; Reinhold, Bruce B.; Lee, Sun Young; Zhang, Guanglan; Lank, Simon; O’Connor, David H.; Berkowitz, Ross Stuart; Brusic, Vladimir; Kim, Seung Jo; Reinherz, Ellis Leonard (Frontiers Research Foundation, 2011)
      Persistent infection with high-risk human papilloma viruses (HPV) is the worldwide cause of many cancers, including cervical, anal, vulval, vaginal, penile, and oropharyngeal. Since T cells naturally eliminate the majority ...
    • Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis 

      Worley, Michael Joe; Welch, William Robert; Berkowitz, Ross Stuart; Ng, Shu-Wing (Molecular Diversity Preservation International (MDPI), 2013)
      Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, ...
    • Etiology and Pathogenesis of Epithelial Ovarian Cancer 

      Mok, Samuel C.; Kwong, Joseph; Welch, William R.; Samimi, Goli; Ozbun, Laurent; Bonome, Tomas; Birrer, Michael J.; Berkowitz, Ross S.; Wong, Kwong-Kwok (IOS Press, 2007)
      Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological ...
    • Gene Expression Signature of Normal Cell-of-Origin Predicts Ovarian Tumor Outcomes 

      Merritt, Melissa A.; Bentink, Stefan; Schwede, Matthew; Iwanicki, Marcin P.; Quackenbush, John; Woo, Terri; Agoston, Elin S.; Reinhardt, Ferenc; Crum, Christopher P.; Berkowitz, Ross S.; Mok, Samuel C.; Witt, Abigail E.; Jones, Michelle A.; Wang, Bin; Ince, Tan A. (Public Library of Science, 2013)
      The potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct cells-of-origin may play a role in determining ovarian tumor phenotype ...
    • Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells 

      Zhang, Yanli; Kwok, Jamie Sui-Lam; Choi, Pui-Wah; Liu, Minghua; Yang, Junzheng; Singh, Margit; Ng, Shu-Kay; Welch, William R.; Muto, Michael G.; Tsui, Stephen KW; Sugrue, Stephen P.; Berkowitz, Ross S.; Ng, Shu-Wing (Impact Journals LLC, 2016)
      Unlike many other human solid tumors, ovarian tumors express many epithelial markers at a high level for cell growth and local invasion. The phosphoprotein Pinin plays a key role in epithelial cell identity. We showed that ...
    • Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome 

      Wang, Z. C.; Birkbak, N; Culhane, Aedin; Drapkin, R; Fatima, Aquila; Tian, R; Schwede, M.; Alsop, K.; Daniels, K. E.; Piao, H.; Liu, Joy; Etemadmoghadam, D.; Miron, A; Salvesen, H. B.; Mitchell, G.; DeFazio, A.; Quackenbush, John; Berkowitz, Ross Stuart; Iglehart, James Dirk; Bowtell, D. D. L.; Matulonis, Ursula Anne (American Association for Cancer Research (AACR), 2012)
      Purpose—High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination repair (HRR) are associated with genomic instability in ...