Now showing items 1-6 of 6

    • Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis 

      Gaudet, Suzanne; Spencer, Sabrina L.; Chen, William Wei-Lun; Sorger, Peter Karl (Public Library of Science, 2012)
      Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL (TNF-related apoptosis-inducing ligand) variability ...
    • Lyapunov Exponents and Phase Diagrams Reveal Multi-Factorial Control over TRAIL-Induced Apoptosis 

      Aldridge, Bree Beardsley; Gaudet, Suzanne; Lauffenburger, Douglas A.; Sorger, Peter Karl (Nature Publishing Group, 2011)
      Receptor-mediated apoptosis proceeds via two pathways: one requiring only a cascade of initiator and effector caspases (type I behavior) and the second requiring an initiator–effector caspase cascade and mitochondrial outer ...
    • The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring 

      Gaudet, Suzanne; Langlois, Marie-Josée; Lue, Robert Arnold; Rivard, Nathalie; Viel, Alain (BioMed Central, 2011)
      Background: The human homologue of the Drosophila Discs-large tumor suppressor protein, hDlg, is a multi-domain cytoplasmic protein that localizes to the membrane at intercellular junction sites. At both synaptic junctions ...
    • NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor 

      Lee, Robin E. C.; Qasaimeh, Mohammad A.; Xia, Xianfang; Juncker, David; Gaudet, Suzanne (Nature Publishing Group, 2016)
      In tissues and tumours, cell behaviours are regulated by multiple time-varying signals. While in the laboratory cells are often exposed to a stimulus for the duration of the experiment, in vivo exposures may be much shorter. ...
    • A Reference Map of the Human Binary Protein Interactome 

      Luck, Katja; Kim, Dae-Kyum; Lambourne, Luke; Spirohn, Kerstin; Begg, Bridget E; Bian, Wenting; Brignall, Ruth; Cafarelli, Tiziana; Campos-Laborie, Francisco J.; Charloteaux, Benoit; Choi, Dongsic; Coté, Atina; Daley, Meaghan; Deimling, Steven; Desbuleux, Alice; Dricot, Amélie; Gebbia, Marinella; Hardy, Madeleine; Kishore, Nishka; Knapp, Jennifer; Kovács, István A.; Lemmens, Irma; Mee, Miles W.; Mellor, Joseph C.; Pollis, Carl; Pons, Carles; Richardson, Aaron; Schlabach, Sadie; Teeking, Bridget; Yadav, Anupama; Babor, Mariana; Balcha, Dawit; Basha, Omer; Bowman-Colin, Christian; Chin, Suet-Feung; Choi, Soon Gang; Colabella, Claudia; Coppin, Georges; D'Amata, Cassandra; De Ridder, David; De Rouck, Steffi; Duran-Frigola, Miquel; Ennajdaoui, Hanane; Goebels, Florian; Goehring, Liana; Gopal, Anjali; Haddad, Ghazal; Hatchi, Elodie; Helmy, Mohamed; Jacob, Yves; Kassa, Yoseph; Landini, Serena; Li, Roujia; van Lieshout, Natascha; MacWilliams, Andrew; Markey, Dylan; Paulson, Joseph; Rangarajan, Sudharshan; Rasla, John; Rayhan, Ashyad; Rolland, Thomas; San Miguel Delgadillo, Adriana; Shen, Yun; Sheykhkarimli, Dayag; Sheynkman, Gloria; Simonovsky, Eyal; Taşan, Murat; Tejeda, Alexander; Tropepe, Vincent; Twizere, Jean-Claude; Wang, Yang; Weatheritt, Robert; Weile, Jochen; Xia, Yu; Yang, Xinping; Yeger-Lotem, Esti; Zhong, Quan; Aloy, Patrick; Bader, Gary D.; De Las Rivas, Javier; Gaudet, Suzanne; Hao, Tong; Rak, Janusz; Tavernier, Jan; Hill, David; Vidal, Marc; Roth, Frederick P.; Calderwood, Michael (Nature Research, 2020-04-08)
      Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships. Here, we present a human “all-by-all” reference ...
    • Systemic Calibration of a Cell Signaling Network Model 

      Spencer, Sabrina Leigh; Albeck, John Gerald; Burke, John M.; Sorger, Peter Karl; Gaudet, Suzanne; Kim, Kyoung Ae; Kim, Do Hyun (BioMed Central, 2010)
      Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental data is often challenging and a rate limiting ...