Browsing by Author "Humbert, Michael"

Now showing items 1-6 of 6

    • An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV 

      Hemashettar, Girish; Wang, Wendy; Novembre, Francis J.; Villinger, Francois; Ibegbu, Chris; Patel, Kalpana; Corti, Davide; Agatic, Gloria; Vanzetta, Fabrizia; Bianchi, Siro; Heeney, Jonathan L.; Sallusto, Federica; Lanzavecchia, Antonio; Watkins, Jennifer D; Siddappa, Nagadenahalli B.; Lakhashe, Samir; Humbert, Michael; Sholukh, Anton M; Wong, Yin Ling; Yoon, John C.; Ruprecht, Ruth Margrit (Public Library of Science, 2011)
      Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer ...

    • Identification of Mimotopes with Diagnostic Potential for Trypanosoma brucei gambiense Variant Surface Glycoproteins Using Human Antibody Fractions 

      Van Nieuwenhove, Liesbeth; Büscher, Philippe; Balharbi, Fatima; Humbert, Michael; Dieltjens, Tessa; Guisez, Yves; Lejon, Veerle (Public Library of Science, 2012)
      Background: At present, screening of the population at risk for gambiense human African trypanosomiasis (HAT) is based on detection of antibodies against native variant surface glycoproteins (VSGs) of Trypanosoma brucei ...

    • Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing 

      Humbert, Michael; Rasmussen, Robert Anthony; Ong, Helena; Kaiser, Fabian M. P.; Hu, Shiu-Lok; Ruprecht, Ruth Margrit (Public Library of Science, 2008)
      Background: Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We ...

    • Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity 

      Sholukh, Anton M.; Mukhtar, Muhammad Mahmood; Humbert, Michael; Essono, Sosthène S.; Watkins, Jennifer D.; Vyas, Hemant Kumar; Shanmuganathan, Vivekanandan; Hemashettar, Girish; Kahn, Maria; Hu, Shiu-Lok; Montefiori, David C.; Polonis, Victoria R.; Schur, Peter Henry; Ruprecht, Ruth Margrit (Public Library of Science, 2012)
      Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics ...

    • Live-virus exposure of vaccine-protected macaques alters the anti-HIV-1 antibody repertoire in the absence of viremia 

      Bachler, Barbara C; Humbert, Michael; Lakhashe, Samir K; Rasmussen, Robert A; Ruprecht, Ruth M (BioMed Central, 2013)
      Background: We addressed the question whether live-virus challenges could alter vaccine-induced antibody (Ab) responses in vaccinated rhesus macaques (RMs) that completely resisted repeated exposures to R5-tropic simian-human ...

    • SHIV-1157i and Passaged Progeny Viruses Encoding R5 HIV-1 Clade C Env Cause AIDS in Rhesus Monkeys 

      Song, Ruijiang; Ong, Helena; Sharma, Prachi; Chenine, Agnès L; Kramer, Victor G; Xu, Weidong; Else, James G; Novembre, Francis J; Strobert, Elizabeth; O'Neil, Shawn P; Humbert, Michael; Rasmussen, Robert Anthony; Siddappa, Nagadenahalli B.; Ruprecht, Ruth Margrit (BioMed Central, 2008)
      Background: Infection of nonhuman primates with simian immunodeficiency virus (SIV) or chimeric simian-human immunodeficiency virus (SHIV) strains is widely used to study lentiviral pathogenesis, antiviral immunity and the ...