Now showing items 1-7 of 7

    • GADD45α and γ interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration 

      Tamura, Rodrigo E.; Paccez, Juliano D.; Duncan, Kristal C.; Morale, Mirian G.; Simabuco, Fernando M.; Dillon, Simon; Correa, Ricardo G.; Gu, Xuesong; Libermann, Towia A.; Zerbini, Luiz F. (Impact Journals LLC, 2016)
      The epithelium-specific Ets transcription factor, SPDEF, plays a critical role in metastasis of prostate and breast cancer cells. While enhanced SPDEF expression blocks migration and invasion, knockdown of SPDEF expression ...
    • Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies 

      Kumar, Pramod; Satyam, Abhigyan; Fan, Xingliang; Collin, Estelle; Rochev, Yury; Rodriguez, Brian J.; Gorelov, Alexander; Dillon, Simon; Joshi, Lokesh; Raghunath, Michael; Pandit, Abhay; Zeugolis, Dimitrios I. (Nature Publishing Group, 2015)
      Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ...
    • Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer 

      Jedinak, Andrej; Curatolo, Adam; Zurakowski, David; Dillon, Simon; Bhasin, Manoj K; Libermann, Towia A; Roy, Roopali; Sachdev, Monisha; Loughlin, Kevin R; Moses, Marsha A (BioMed Central, 2015)
      Background: The objective of this study was to discover and to validate novel noninvasive biomarkers that distinguish between benign prostate hyperplasia (BPH) and localized prostate cancer (PCa), thereby helping to solve ...
    • Preliminary Biomarkers for Identification of Human Ascending Thoracic Aortic Aneurysm 

      Black, Kendra M.; Masuzawa, Akihiro; Hagberg, Robert C.; Khabbaz, Kamal R.; Trovato, Mary E.; Rettagliati, Verna M.; Bhasin, Manoj K.; Dillon, Simon T.; Libermann, Towia A.; Toumpoulis, Ioannis K.; Levitsky, Sidney; McCully, James D. (Blackwell Publishing Ltd, 2013)
      Background: Human ascending thoracic aortic aneurysms (ATAAs) are life threatening and constitute a leading cause of mortality in the United States. Previously, we demonstrated that collagens α2(V) and α1(XI) mRNA and ...
    • Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity 

      Dillon, Simon T; Bhasin, Manoj K; Feng, Xiaoxing; Koh, David W; Daoud, Sayed S (BioMed Central, 2013)
      Background: The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity ...
    • TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release 

      Bunch, Heeyoun; Zheng, Xiaofeng; Burkholder, Adam; Dillon, Simon T.; Motola, Shmulik; Birrane, Gabriel; Ebmeier, Christopher C.; Levine, Stuart; Fargo, David; Hu, Guang; Taatjes, Dylan J.; Calderwood, Stuart K. (2014)
      Summary Promoter proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in transcription. An unbiased search for novel human proteins that could regulate paused Pol II at the HSPA1B gene identified TRIM28. ...
    • Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 

      Junker, Yvonne; Zeissig, Sebastian; Kim, Seong-Jun; Barisani, Donatella; Wieser, Herbert; Leffler, Daniel A.; Zevallos, Victor; Libermann, Towia A.; Dillon, Simon; Freitag, Tobias L.; Kelly, Ciaran P.; Schuppan, Detlef (The Rockefeller University Press, 2012)
      Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in ...